Oxidative stress and systemic changes in age-related macular degeneration

Milam A. Brantley, Melissa P. Osborn, Jiyang Cai, Paul Sternberg

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Several lines of evidence point to a systemic role for oxidative stress in age-related macular degeneration (AMD). Age and smoking are associated with increasing levels of systemic oxidative stress and oral antioxidant supplements have been shown to slow the progression of the disease. In addition, plasma levels of reactive oxygen species and lipid peroxidation products have been closely associated with AMD, and decreased antioxidant enzyme activity has been reported in AMD patients. Polymorphisms in mitochondrial DNA (mtDNA) and in genes coding for antioxidant enzymes have also been linked to AMD. Oxidative stress and inflammatory mediators have been shown to play a role in AMD, although it is unclear whether inflammation is aggravated by oxidative stress or vice versa. As the interaction between inflammation and oxidative stress may be critical to development and progression of AMD, a combination therapy that reduces systemic changes in redox status and controls local inflammation may be able to prevent or at least slow the development of sight-threatening late-stage disease.

Original languageEnglish (US)
Title of host publicationStudies on Retinal and Choroidal Disorders
PublisherHumana Press Inc.
Pages367-397
Number of pages31
ISBN (Electronic)9781617796067
ISBN (Print)9781617796050
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Oxidative stress
Macular Degeneration
Oxidative Stress
Antioxidants
Inflammation
Enzyme activity
Polymorphism
Mitochondrial DNA
Enzymes
Reactive Oxygen Species
Genes
Lipid Peroxidation
Oxidation-Reduction
Disease Progression
Lipids
Plasmas
Smoking

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Brantley, M. A., Osborn, M. P., Cai, J., & Sternberg, P. (2012). Oxidative stress and systemic changes in age-related macular degeneration. In Studies on Retinal and Choroidal Disorders (pp. 367-397). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-606-7_18

Oxidative stress and systemic changes in age-related macular degeneration. / Brantley, Milam A.; Osborn, Melissa P.; Cai, Jiyang; Sternberg, Paul.

Studies on Retinal and Choroidal Disorders. Humana Press Inc., 2012. p. 367-397.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brantley, MA, Osborn, MP, Cai, J & Sternberg, P 2012, Oxidative stress and systemic changes in age-related macular degeneration. in Studies on Retinal and Choroidal Disorders. Humana Press Inc., pp. 367-397. https://doi.org/10.1007/978-1-61779-606-7_18
Brantley MA, Osborn MP, Cai J, Sternberg P. Oxidative stress and systemic changes in age-related macular degeneration. In Studies on Retinal and Choroidal Disorders. Humana Press Inc. 2012. p. 367-397 https://doi.org/10.1007/978-1-61779-606-7_18
Brantley, Milam A. ; Osborn, Melissa P. ; Cai, Jiyang ; Sternberg, Paul. / Oxidative stress and systemic changes in age-related macular degeneration. Studies on Retinal and Choroidal Disorders. Humana Press Inc., 2012. pp. 367-397
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