Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

J. Regino Perez-Polo, Conor B. Reilly, Harriet C. Rea

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

    Original languageEnglish (US)
    Pages (from-to)639-644
    Number of pages6
    JournalInternational Journal of Developmental Neuroscience
    Volume29
    Issue number6
    DOIs
    StatePublished - Oct 1 2011

    Keywords

    • Cyclooxygenase
    • Hyperoxia
    • Hypoxia ischemia
    • Nitric oxide synthase
    • Perinatal ischemia

    ASJC Scopus subject areas

    • Developmental Neuroscience
    • Developmental Biology

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