Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

J. Regino Perez-Polo; Conor B. Reilly; Harriet C. Rea

doi:10.1016/j.ijdevneu.2011.03.009

Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

J. Regino Perez-Polo, Conor B. Reilly, Harriet C. Rea

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 ^cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

Original language	English (US)
Pages (from-to)	639-644
Number of pages	6
Journal	International Journal of Developmental Neuroscience
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/j.ijdevneu.2011.03.009
State	Published - Oct 2011

Keywords

Cyclooxygenase
Hyperoxia
Hypoxia ischemia
Nitric oxide synthase
Perinatal ischemia

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/j.ijdevneu.2011.03.009

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title = "Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex",

abstract = "Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.",

keywords = "Cyclooxygenase, Hyperoxia, Hypoxia ischemia, Nitric oxide synthase, Perinatal ischemia",

author = "Perez-Polo, {J. Regino} and Reilly, {Conor B.} and Rea, {Harriet C.}",

year = "2011",

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AU - Reilly, Conor B.

AU - Rea, Harriet C.

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Y1 - 2011/10

N2 - Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

AB - Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

KW - Cyclooxygenase

KW - Hyperoxia

KW - Hypoxia ischemia

KW - Nitric oxide synthase

KW - Perinatal ischemia

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JO - International Journal of Developmental Neuroscience

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ER -

Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

Abstract

Keywords

ASJC Scopus subject areas

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