Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

J. Regino Perez-Polo, Conor B. Reilly, Harriet C. Rea

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

    Original languageEnglish (US)
    Pages (from-to)639-644
    Number of pages6
    JournalInternational Journal of Developmental Neuroscience
    Volume29
    Issue number6
    DOIs
    StatePublished - Oct 2011

    Fingerprint

    Hyperoxia
    Resuscitation
    Prostaglandins
    Rodentia
    Ischemia
    Oxygen
    Neutrophil Activation
    Leukotrienes
    Protein S
    Dinoprostone
    Brain Injuries
    Oxidative Stress
    Cell Death
    Inflammation
    Hypoxia

    Keywords

    • Cyclooxygenase
    • Hyperoxia
    • Hypoxia ischemia
    • Nitric oxide synthase
    • Perinatal ischemia

    ASJC Scopus subject areas

    • Developmental Biology
    • Developmental Neuroscience

    Cite this

    Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex. / Perez-Polo, J. Regino; Reilly, Conor B.; Rea, Harriet C.

    In: International Journal of Developmental Neuroscience, Vol. 29, No. 6, 10.2011, p. 639-644.

    Research output: Contribution to journalArticle

    Perez-Polo, J. Regino ; Reilly, Conor B. ; Rea, Harriet C. / Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex. In: International Journal of Developmental Neuroscience. 2011 ; Vol. 29, No. 6. pp. 639-644.
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