Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

J. Regino Perez-Polo, Conor B. Reilly, Harriet C. Rea

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2 cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume29
Issue number6
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Cyclooxygenase
  • Hyperoxia
  • Hypoxia ischemia
  • Nitric oxide synthase
  • Perinatal ischemia

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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