Abstract
HIV-1 Tat is a potent transcriptional activator of the viral promoter with the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral as well as cellular proteins. Here, we studied the influence of p73, a protein that is implicated in apoptosis and cell cycle control, on Tat apoptotic function in the central nervous system. We recently demonstrated the ability of Tat to associate with p73, and that this association modulates Tat transcriptional activity (Amini et al., Mol Cell Biol 2005; 18: 8126-8138). We demonstrated that p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes. Thus, the interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1419-1431 |
| Number of pages | 13 |
| Journal | Apoptosis |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2005 |
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Keywords
- Apoptosis
- Astrocytes
- Cytochrome c
- HIV-1
- p73
- Tat
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes. / Saunders, M.; Eldeen, M. B.; Del Valle, L.; Reiss, K.; Peruzzi, F.; Mameli, G.; Gelman, Benjamin; Khalili, K.; Amini, S.; Sawaya, B. E.
In: Apoptosis, Vol. 10, No. 6, 12.2005, p. 1419-1431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
AU - Saunders, M.
AU - Eldeen, M. B.
AU - Del Valle, L.
AU - Reiss, K.
AU - Peruzzi, F.
AU - Mameli, G.
AU - Gelman, Benjamin
AU - Khalili, K.
AU - Amini, S.
AU - Sawaya, B. E.
PY - 2005/12
Y1 - 2005/12
N2 - HIV-1 Tat is a potent transcriptional activator of the viral promoter with the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral as well as cellular proteins. Here, we studied the influence of p73, a protein that is implicated in apoptosis and cell cycle control, on Tat apoptotic function in the central nervous system. We recently demonstrated the ability of Tat to associate with p73, and that this association modulates Tat transcriptional activity (Amini et al., Mol Cell Biol 2005; 18: 8126-8138). We demonstrated that p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes. Thus, the interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients.
AB - HIV-1 Tat is a potent transcriptional activator of the viral promoter with the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral as well as cellular proteins. Here, we studied the influence of p73, a protein that is implicated in apoptosis and cell cycle control, on Tat apoptotic function in the central nervous system. We recently demonstrated the ability of Tat to associate with p73, and that this association modulates Tat transcriptional activity (Amini et al., Mol Cell Biol 2005; 18: 8126-8138). We demonstrated that p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes. Thus, the interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients.
KW - Apoptosis
KW - Astrocytes
KW - Cytochrome c
KW - HIV-1
KW - p73
KW - Tat
UR - http://www.scopus.com/inward/record.url?scp=30944465431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30944465431&partnerID=8YFLogxK
U2 - 10.1007/s10495-005-2467-x
DO - 10.1007/s10495-005-2467-x
M3 - Article
VL - 10
SP - 1419
EP - 1431
JO - Apoptosis : an international journal on programmed cell death
JF - Apoptosis : an international journal on programmed cell death
SN - 1360-8185
IS - 6
ER -