TY - JOUR
T1 - Pancreatic regeneration after partial pancreatectomy
AU - Parekh, Dilipkumar
AU - Townsend, Courtney M.
AU - Rajaraman, Srinivasan
AU - Ishizuka, Jin
AU - Thompson, James C.
N1 - Funding Information:
Supported in part by grants from the National Institutes of Health (5437 DK 15241, PO1 DK 35608), Bethesda, Maryland, and the American Cancer Society (PDT-220), Atlanta, Georgia. Dr. Pare!& is a Visiting Scientist from the University of Witwatersrand, Johannesburg, South Africa, supported by scholarships from the Michael and Janie Miller Foundation and Medical Research Council, South Africa.
PY - 1991/1
Y1 - 1991/1
N2 - The ability of the pancreas to regenerate and the effects of trophic hormones on regeneration of the pancreas after partial pancreatectomy are not completely understood. We investigated the effects of the trypsin inhibitor FOY-305 (an agent that stimulates endogenous cholecystokinin) on pancreatic regeneration after partial pancreatectomy in rats. FOY-305 or water was administered for either 13 days or 27 days by gavage feeding, after sham operation or partial pancreatectomy (n = 6 to 8 animals per group). FOY-305 stimulated hypertrophy of the pancreatic remnant at 13 days; prolonged treatment for 27 days produced both hypertrophy and hyperplasia. The magnitude of pancreatic growth after FOY-305 administration was significantly greater at 27 days in the pancreatic remnant than growth of the equivalent pancreatic segment (duodenal and parabiliary) in sham-operated rats treated with FOY-305. Our results suggest that endogenous cholecystokinin released by FOY-305 stimulates regeneration after partial pancreatectomy. The pancreatic remnant is more sensitive to trophic stimulation in comparison to the normal pancreas. FOY-305 may be a useful agent in the treatment of pancreatic insufficiency after extensive subtotal pancreatectomy or chronic pancreatitis.
AB - The ability of the pancreas to regenerate and the effects of trophic hormones on regeneration of the pancreas after partial pancreatectomy are not completely understood. We investigated the effects of the trypsin inhibitor FOY-305 (an agent that stimulates endogenous cholecystokinin) on pancreatic regeneration after partial pancreatectomy in rats. FOY-305 or water was administered for either 13 days or 27 days by gavage feeding, after sham operation or partial pancreatectomy (n = 6 to 8 animals per group). FOY-305 stimulated hypertrophy of the pancreatic remnant at 13 days; prolonged treatment for 27 days produced both hypertrophy and hyperplasia. The magnitude of pancreatic growth after FOY-305 administration was significantly greater at 27 days in the pancreatic remnant than growth of the equivalent pancreatic segment (duodenal and parabiliary) in sham-operated rats treated with FOY-305. Our results suggest that endogenous cholecystokinin released by FOY-305 stimulates regeneration after partial pancreatectomy. The pancreatic remnant is more sensitive to trophic stimulation in comparison to the normal pancreas. FOY-305 may be a useful agent in the treatment of pancreatic insufficiency after extensive subtotal pancreatectomy or chronic pancreatitis.
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U2 - 10.1016/0002-9610(91)90365-K
DO - 10.1016/0002-9610(91)90365-K
M3 - Article
C2 - 1702941
AN - SCOPUS:0026100553
SN - 0002-9610
VL - 161
SP - 84
EP - 89
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 1
ER -