Pancreatic Secretion in Man: Effect of Fasting, Drugs, Pancreatic Enzymes, and Somatostatin

Bhupinderjit S. Anand, Richard Goodgame, David Y. Graham

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The inhibitory effecl of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic‐cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide., and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 g bid given subcutaneous I y; increasing the dose up to 100 Hg tid had no additional benefit. A stable pancreatic‐cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalThe American Journal of Gastroenterology
Volume89
Issue number2
DOIs
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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