Pancreatic secretion in man: Effect of fasting, drugs, pancreatic enzymes, and somatostatin

B. S. Anand, R. Goodgame, D. Y. Graham

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The inhibitory effect of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic-cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide, and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 μg bid given subcutaneously; increasing the dose up to 100 μg tid had no additional benefit. A stable pancreatic-cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume89
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Octreotide
Somatostatin
Cutaneous Fistula
Pancreatic Fistula
Fasting
Propantheline
Enzymes
Pharmaceutical Preparations
Acetazolamide
Cimetidine
Therapeutic Uses
Verapamil

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pancreatic secretion in man : Effect of fasting, drugs, pancreatic enzymes, and somatostatin. / Anand, B. S.; Goodgame, R.; Graham, D. Y.

In: American Journal of Gastroenterology, Vol. 89, No. 2, 1994, p. 267-270.

Research output: Contribution to journalArticle

Anand, B. S. ; Goodgame, R. ; Graham, D. Y. / Pancreatic secretion in man : Effect of fasting, drugs, pancreatic enzymes, and somatostatin. In: American Journal of Gastroenterology. 1994 ; Vol. 89, No. 2. pp. 267-270.
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