The inhibitory effecl of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic‐cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide., and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 g bid given subcutaneous I y; increasing the dose up to 100 Hg tid had no additional benefit. A stable pancreatic‐cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
|Number of pages
|The American Journal of Gastroenterology
|Published - Feb 1994
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