Paracorporeal artificial lung as a bridge to recovery or lung transplant

Joseph B. Zwischenberger, Dongfang Wang, Scott D. Lick, Scott K. Alpard, Clare Savage, Donald J. Deyo, Akhil Bidani, Sean Chambers

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    A Paracorporeal Artificial Lung (PAL) was designed and built by MC 3 Corporation for high gas exchange efficiency and low blood flow resistance as a bridge to recovery or lung transplant. The initial PAL implanted in a pulmonary artery-to-artery (PA-PA) configuration supported gas exchange in normal sheep (n=8) up to 7 days. 4/8 sheep survived, but 4/8 experienced right heart failure. Following modifications to lower resistance with an inflow compliance chamber, 6/7 exhibited good cardiac function and total gas exchange for 72 h. We identified several additional complications including acute massive hemothorax (2/24), late (>24 h) hemothorax (4/24), cannula kinking (2/24), and anastomotic stricture (3/24). We addressed bleeding by a heparin free window and reduced dose, changed cannulae position and used Gore-Tex reinforced graft. We then encountered no hemothorax or outflow obstruction. Using our LD 100 smoke/burn ARDS sheep model, we compared PAL (n=8) to volume-controlled mechanical ventilation (VCMV, n=6) in a prospective, randomized, controlled, unblinded, outcomes study to assess outcomes. Both groups were managed with a VCMV algorithm. 6/8 PAL vs. 1/6 VCMV sheep survived the 5-day study. Next, we will study impact on survival and pathophysiology from a LD 100 smoke/burn injury using injection molded PALs with biocompatible surfaces.

    Original languageEnglish (US)
    Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
    Pages1583-1584
    Number of pages2
    Volume2
    StatePublished - 2002
    EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
    Duration: Oct 23 2002Oct 26 2002

    Other

    OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
    CountryUnited States
    CityHouston, TX
    Period10/23/0210/26/02

    Fingerprint

    Transplants
    Gases
    Smoke
    Recovery
    Grafts
    Heparin
    Blood
    Industry

    Keywords

    • ARDS
    • Artificial lung
    • Lung transplantation

    ASJC Scopus subject areas

    • Bioengineering

    Cite this

    Zwischenberger, J. B., Wang, D., Lick, S. D., Alpard, S. K., Savage, C., Deyo, D. J., ... Chambers, S. (2002). Paracorporeal artificial lung as a bridge to recovery or lung transplant. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1583-1584)

    Paracorporeal artificial lung as a bridge to recovery or lung transplant. / Zwischenberger, Joseph B.; Wang, Dongfang; Lick, Scott D.; Alpard, Scott K.; Savage, Clare; Deyo, Donald J.; Bidani, Akhil; Chambers, Sean.

    Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. p. 1583-1584.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Zwischenberger, JB, Wang, D, Lick, SD, Alpard, SK, Savage, C, Deyo, DJ, Bidani, A & Chambers, S 2002, Paracorporeal artificial lung as a bridge to recovery or lung transplant. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1583-1584, Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 10/23/02.
    Zwischenberger JB, Wang D, Lick SD, Alpard SK, Savage C, Deyo DJ et al. Paracorporeal artificial lung as a bridge to recovery or lung transplant. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2002. p. 1583-1584
    Zwischenberger, Joseph B. ; Wang, Dongfang ; Lick, Scott D. ; Alpard, Scott K. ; Savage, Clare ; Deyo, Donald J. ; Bidani, Akhil ; Chambers, Sean. / Paracorporeal artificial lung as a bridge to recovery or lung transplant. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. pp. 1583-1584
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