Paradigm shifts and explanation in clinical medicine: The "how" of reality and the "why" of truth

Alireza Ghaffari, Mohammadali M. Shoja, R. Shane Tubbs, Marios Loukas, Paul S. Agutter, Kamyar Ghabili, Jalal Etemadi, Aaron A. Cohen-Gadol, Bradley K. Weiner

Research output: Chapter in Book/Report/Conference proceedingChapter


The philosophy of science in general, and the philosophy of biology in particular, arerelevant to scientific medicine. However, contemporary medical understanding raisesdistinct and perhaps unique ontological and epistemological issues that merit separate consideration, not least because they can have implications for practice. In this paper, weidentify some of these issues, using the current controversy surrounding the treatment ofanemia in cases of chronic kidney disease as exemplar. The preliminary inferences drawnfrom this discussion are presented as starting points for more detailed exploration byphilosophers, as well as matters for attention by clinicians.

Original languageEnglish (US)
Title of host publicationHypotheses in Clinical Medicine
PublisherNova Science Publishers, Inc.
Number of pages10
ISBN (Print)9781622572762
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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