Paraprotein-related kidney disease: Glomerular diseases associated with paraproteinemias

Shveta S. Motwani, Leal Herlitz, Divya Monga, Kenar D. Jhaveri, Albert Q. Lam

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Paraproteins are monoclonal Igs that accumulate in blood as a result of abnormal excess production. These circulating proteins cause a diversity of kidney disorders that are increasingly being comanaged by nephrologists. In this review,we discuss paraprotein-related diseases that affect the glomerulus.We provide a broad overview of diseases characterized by nonorganized deposits, such as monoclonal Ig deposition disease (MIDD), proliferative GN with monoclonal Ig deposits (PGNMID), and C3 glomerulopathy, as well as those characterized by organized deposits, such as amyloidosis, immunotactoid glomerulopathy, fibrillaryGN, and cryoglobulinemicGN, and rarer disorders, such as monoclonal crystalline glomerulopathies, paraprotein-related thrombotic microangiopathies, and membranous-like glomerulopathy with masked IgGκ deposits. This review will provide the nephrologist with an up to date understanding of these entities and highlight the areas of deficit in evidence and future lines of research.

Original languageEnglish (US)
Pages (from-to)2260-2272
Number of pages13
JournalClinical Journal of the American Society of Nephrology
Issue number12
StatePublished - 2016
Externally publishedYes


  • Amyloidosis
  • Cast nephropathy
  • Kidney
  • Kidney Diseases
  • Light chains
  • Monoclonal paraprotein
  • Multiple myeloma M-proteins
  • Myeloma Proteins
  • Paraproteins
  • Social Behavior

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


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