Abstract
Microdialysis was used to administer paraquat into the spinal cord of the anesthetized rat to determine the effects of the in vivo generation of the superoxide anion (O2 ·-) on neurons. Exposure to paraquat caused blockage of axonal conduction, destruction of the cell bodies of neurons, and a general release of amino acids. Thus, paraquat is quite harmful to neuronal tissue. Similarities between paraquat-induced damage and that previously observed from the hydroxyl radical are consistent with paraquat, causing damage by generation of reactive oxygen species and the widespread belief that generation of O2 ·- initiates the formation of destructive reactive oxygen species in a wide variety of traumas and other disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 861-867 |
| Number of pages | 7 |
| Journal | Free Radical Biology and Medicine |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- Free radicals
- Microdialysis
- Neurotrauma
- Peroxidation
- Reactive oxygen species
- Spinal cord
- Superoxide
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)
- Clinical Biochemistry
- Medicine(all)
- Toxicology
Cite this
Paraquat - A superoxide generator - Kills neurons in the rat spinal cord. / Liu, Danxia; Yang, Jinping; Li, Liping; McAdoo, David J.
In: Free Radical Biology and Medicine, Vol. 18, No. 5, 1995, p. 861-867.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paraquat - A superoxide generator - Kills neurons in the rat spinal cord
AU - Liu, Danxia
AU - Yang, Jinping
AU - Li, Liping
AU - McAdoo, David J.
PY - 1995
Y1 - 1995
N2 - Microdialysis was used to administer paraquat into the spinal cord of the anesthetized rat to determine the effects of the in vivo generation of the superoxide anion (O2 ·-) on neurons. Exposure to paraquat caused blockage of axonal conduction, destruction of the cell bodies of neurons, and a general release of amino acids. Thus, paraquat is quite harmful to neuronal tissue. Similarities between paraquat-induced damage and that previously observed from the hydroxyl radical are consistent with paraquat, causing damage by generation of reactive oxygen species and the widespread belief that generation of O2 ·- initiates the formation of destructive reactive oxygen species in a wide variety of traumas and other disorders.
AB - Microdialysis was used to administer paraquat into the spinal cord of the anesthetized rat to determine the effects of the in vivo generation of the superoxide anion (O2 ·-) on neurons. Exposure to paraquat caused blockage of axonal conduction, destruction of the cell bodies of neurons, and a general release of amino acids. Thus, paraquat is quite harmful to neuronal tissue. Similarities between paraquat-induced damage and that previously observed from the hydroxyl radical are consistent with paraquat, causing damage by generation of reactive oxygen species and the widespread belief that generation of O2 ·- initiates the formation of destructive reactive oxygen species in a wide variety of traumas and other disorders.
KW - Free radicals
KW - Microdialysis
KW - Neurotrauma
KW - Peroxidation
KW - Reactive oxygen species
KW - Spinal cord
KW - Superoxide
UR - http://www.scopus.com/inward/record.url?scp=0028897694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028897694&partnerID=8YFLogxK
U2 - 10.1016/0891-5849(94)00214-5
DO - 10.1016/0891-5849(94)00214-5
M3 - Article
C2 - 7797093
AN - SCOPUS:0028897694
VL - 18
SP - 861
EP - 867
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
IS - 5
ER -