Abstract
Microdialysis was used to administer paraquat into the spinal cord of the anesthetized rat to determine the effects of the in vivo generation of the superoxide anion (O2·-) on neurons. Exposure to paraquat caused blockage of axonal conduction, destruction of the cell bodies of neurons, and a general release of amino acids. Thus, paraquat is quite harmful to neuronal tissue. Similarities between paraquat-induced damage and that previously observed from the hydroxyl radical are consistent with paraquat, causing damage by generation of reactive oxygen species and the widespread belief that generation of O2·- initiates the formation of destructive reactive oxygen species in a wide variety of traumas and other disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 861-867 |
| Number of pages | 7 |
| Journal | Free Radical Biology and Medicine |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1995 |
Keywords
- Free radicals
- Microdialysis
- Neurotrauma
- Peroxidation
- Reactive oxygen species
- Spinal cord
- Superoxide
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)
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Liu, D., Yang, J., Li, L., & McAdoo, D. J. (1995). Paraquat - A superoxide generator - Kills neurons in the rat spinal cord. Free Radical Biology and Medicine, 18(5), 861-867. https://doi.org/10.1016/0891-5849(94)00214-5