Parkinson's disease is an autoimmune disease: A reappraisal

Srinivasa Reddy Bonam, Sylviane Muller

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Parkinson's disease (PD) is a common, age-related, neurodegenerative disorder characterized by motor deficits and a cognitive decline. In the large majority of cases, it is associated with cytoplasmic aggregation of α-synuclein/SNCA and the formation of Lewy bodies in the dopamine neurons in the substantia nigra pars compacta. The etiopathogenesis of PD remains poorly understood. The disease results from an interplay of genetic and environmental factors, including pharmacological molecules, which destroy dopaminergic neurons. Recently, several notable data have highlighted various immune alterations underlying that PD is associated to autoimmune features and could be considered as an autoimmune disease. In this short article, we briefly review key elements participating to this emerging viewpoint.

Original languageEnglish (US)
Article number102684
JournalAutoimmunity Reviews
Volume19
Issue number12
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • Autoimmunity
  • Autophagy
  • Parkinson's disease
  • Therapy
  • α-Synuclein/SNCA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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