PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

Medicine & Life Sciences

• Poly (ADP-Ribose) Polymerase-1 93%
• Chagas Disease 80%
• Mitochondrial DNA 71%
• Maintenance 47%
• Heart 44%
• Cardiac Myocytes 18%
• Myocardium 16%
• Trypanosoma cruzi 16%
• N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride 11%
• Poly ADP Ribosylation 10%
• Oxidative Stress 9%
• Poly(ADP-ribose) Polymerase Inhibitors 8%
• Gene Expression 8%
• Oxidative Phosphorylation 7%
• Oxidants 7%
• Left Ventricular Function 6%
• Cardiomyopathies 6%
• DNA Repair 6%
• Mitochondria 5%
• Collagen 5%
• Antioxidants 5%
• Chronic Disease 5%

Agriculture & Biology

• NAD ADP-ribosyltransferase 100%
• Chagas disease 83%
• mitochondrial DNA 56%
• heart 52%
• cardiomyocytes 24%
• mice 23%
• Trypanosoma cruzi 23%
• myocardium 21%
• oxidative stress 10%
• cardiomyopathy 9%
• lung function 8%
• gene expression 8%
• oxidative phosphorylation 7%
• DNA repair 7%
• oxidants 6%
• nuclear genome 6%
• collagen 5%
• translation (genetics) 5%
• therapeutics 5%
• mitochondria 5%
• transcription (genetics) 5%