We administered indomethacin (25 mg q.i.d.) two patients with common variable immunodeficiency and measured the effect on their depressed cellular immune responses. The in vitro response of both patients' lymphocytes to phytohemagglutinin increased during indomethacin administration. Both patients were anergic to skin testing before treatment and responded to two of four skin tests during treatment with indomethacin. Thus indomethacin administration in vivo appears to enhance the cellular immune response, paralleling its previously described effects in vitro.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Clinical and Laboratory Immunology|
|State||Published - Dec 1 1978|
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