Partial reversal of the cellular immune defect in common variable immunodeficiency with indomethacin

J. S. Goodwin, A. D. Bankhurst, S. A. Murphy, D. S. Selinger, R. P. Messner, R. C. Williams

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Abstract

We administered indomethacin (25 mg q.i.d.) two patients with common variable immunodeficiency and measured the effect on their depressed cellular immune responses. The in vitro response of both patients' lymphocytes to phytohemagglutinin increased during indomethacin administration. Both patients were anergic to skin testing before treatment and responded to two of four skin tests during treatment with indomethacin. Thus indomethacin administration in vivo appears to enhance the cellular immune response, paralleling its previously described effects in vitro.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalJournal of Clinical and Laboratory Immunology
Volume1
Issue number3
StatePublished - Dec 1 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Goodwin, J. S., Bankhurst, A. D., Murphy, S. A., Selinger, D. S., Messner, R. P., & Williams, R. C. (1978). Partial reversal of the cellular immune defect in common variable immunodeficiency with indomethacin. Journal of Clinical and Laboratory Immunology, 1(3), 197-199.