Partner disclosure and early CD4 response among HIV-infected adults initiating antiretroviral treatment in Nairobi Kenya

T. Tony Trinh, Nelly Yatich, Richard Ngomoa, Christine J. McGrath, Barbra A. Richardson, Samah R. Sakr, Agnes Langat, Grace C. John-Stewart, Michael H. Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Disclosure of HIV serostatus can have significant benefits for people living with HIV/AIDS. However, there is limited data on whether partner disclosure influences ART treatment response. Methods: We conducted a retrospective cohort study of newly diagnosed, ART-naïve HIV-infected adults (>18 years) who enrolled at the Coptic Hope Center in Nairobi, Kenya between January 1st 2009 and July 1st 2011 and initiated ART within 3 months. Analysis was restricted to adults who reported to have either disclosed or not disclosed their HIV status to their partner. Analysis of CD4 response at 6 and 12 months post-ART was stratified by age group. Results: Among 615 adults newly initiating ART with partner disclosure data and 12 month followup, mean age was 38 years and 52% were male; 76% reported that they had disclosed their HIV-status to their partner. Those who disclosed were significantly younger and more likely to be married/cohabitating than non-disclosers. At baseline, median CD4 counts were similar between disclosure groups. Among younger adults (< 38 years) those who disclosed had higher CD4 recovery than those who did not at 6 months post-ART (mean difference = 31, 95% CI 3 to 58 p = 0.03) but not at 12 months (mean difference = 17, 95% CI -19 to 52, p = 0.4). Among older adults (≥ 38years) there was no observed difference in CD4 recovery at 6 or 12 months between disclosure groups. Conclusion: Among younger adults, disclosure of HIV status to partners may be associated with CD4 recovery following ART.

Original languageEnglish (US)
Article numbere0163594
JournalPLoS One
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2016

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Kenya
Disclosure
HIV
young adults
Recovery
cohort studies
Young Adult
Hope
Therapeutics
CD4 Lymphocyte Count
Acquired Immunodeficiency Syndrome
Cohort Studies
Retrospective Studies
Age Groups
methodology

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Trinh, T. T., Yatich, N., Ngomoa, R., McGrath, C. J., Richardson, B. A., Sakr, S. R., ... Chung, M. H. (2016). Partner disclosure and early CD4 response among HIV-infected adults initiating antiretroviral treatment in Nairobi Kenya. PLoS One, 11(10), [e0163594]. https://doi.org/10.1371/journal.pone.0163594

Partner disclosure and early CD4 response among HIV-infected adults initiating antiretroviral treatment in Nairobi Kenya. / Trinh, T. Tony; Yatich, Nelly; Ngomoa, Richard; McGrath, Christine J.; Richardson, Barbra A.; Sakr, Samah R.; Langat, Agnes; John-Stewart, Grace C.; Chung, Michael H.

In: PLoS One, Vol. 11, No. 10, e0163594, 01.10.2016.

Research output: Contribution to journalArticle

Trinh, TT, Yatich, N, Ngomoa, R, McGrath, CJ, Richardson, BA, Sakr, SR, Langat, A, John-Stewart, GC & Chung, MH 2016, 'Partner disclosure and early CD4 response among HIV-infected adults initiating antiretroviral treatment in Nairobi Kenya', PLoS One, vol. 11, no. 10, e0163594. https://doi.org/10.1371/journal.pone.0163594
Trinh, T. Tony ; Yatich, Nelly ; Ngomoa, Richard ; McGrath, Christine J. ; Richardson, Barbra A. ; Sakr, Samah R. ; Langat, Agnes ; John-Stewart, Grace C. ; Chung, Michael H. / Partner disclosure and early CD4 response among HIV-infected adults initiating antiretroviral treatment in Nairobi Kenya. In: PLoS One. 2016 ; Vol. 11, No. 10.
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