TY - JOUR
T1 - Pathogenesis of Common Ocular Diseases
T2 - Emerging Trends in Extracellular Matrix Remodeling
AU - Ghorbani, Raziyeh
AU - Rasouli, Mehdi
AU - Sefat, Farshid
AU - Heidari Keshel, Saeed
N1 - Publisher Copyright:
© 2023 Taylor & Francis.
PY - 2024
Y1 - 2024
N2 - The prevalence of visual impairments in human societies is worrying due to retinopathy complications of several chronic diseases such as diabetes, cardiovascular diseases, and many more that are on the rise worldwide. Since the proper function of this organ plays a pivotal role in people’s quality of life, identifying factors affecting the development/exacerbation of ocular diseases is of particular interest among ophthalmology researchers. The extracellular matrix (ECM) is a reticular, three-dimensional (3D) structure that determines the shape and dimensions of tissues in the body. The ECM remodeling/hemostasis is a critical process in both physiological and pathological conditions. It consists of ECM deposition, degradation, and decrease/increase in the ECM components. However, disregulation of this process and an imbalance between the synthesis and degradation of ECM components are associated with many pathological situations, including ocular disorders. Despite the impact of ECM alterations on the development of ocular diseases, there is not much research conducted in this regard. Therefore, a better understanding in this regard, can pave the way toward discovering plausible strategies to either prevent or treat eye disorders. In this review, we will discuss the importance of ECM changes as a sentimental factor in various ocular diseases based on the research done up to now.
AB - The prevalence of visual impairments in human societies is worrying due to retinopathy complications of several chronic diseases such as diabetes, cardiovascular diseases, and many more that are on the rise worldwide. Since the proper function of this organ plays a pivotal role in people’s quality of life, identifying factors affecting the development/exacerbation of ocular diseases is of particular interest among ophthalmology researchers. The extracellular matrix (ECM) is a reticular, three-dimensional (3D) structure that determines the shape and dimensions of tissues in the body. The ECM remodeling/hemostasis is a critical process in both physiological and pathological conditions. It consists of ECM deposition, degradation, and decrease/increase in the ECM components. However, disregulation of this process and an imbalance between the synthesis and degradation of ECM components are associated with many pathological situations, including ocular disorders. Despite the impact of ECM alterations on the development of ocular diseases, there is not much research conducted in this regard. Therefore, a better understanding in this regard, can pave the way toward discovering plausible strategies to either prevent or treat eye disorders. In this review, we will discuss the importance of ECM changes as a sentimental factor in various ocular diseases based on the research done up to now.
KW - ECM components, ocular disorders, pathogenesis
KW - ECM remodeling
KW - Extracellular matrix (ECM)
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U2 - 10.1080/08820538.2023.2233601
DO - 10.1080/08820538.2023.2233601
M3 - Review article
C2 - 37424085
AN - SCOPUS:85164745251
SN - 0882-0538
VL - 39
SP - 27
EP - 39
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
IS - 1
ER -