Abstract
The pathogenesis of diffuse intimal thickening (DIT) is not well understood. In animals, it is positively correlated with size, and with the exception of the pig, is thought to involve the proximal more than the distal portions of vessels. DIT is often not visible grossly, so that it's study requires extensive microscopic sampling of tissue. Review of previous studies in animals suggests that microscopic sampling may not have been sufficient to determine exactly where DIT occurs throughout the entire length of a vessel. The present study is a longitudinal step-serial section examination of the entire descending thoracic aorta from 12 adult non-human primates of varying size and species and with varying degrees of DIT as determined previously by more limited cross-section techniques. The findings indicate that DIT is not more pronounced in the proximal versus the distal segments of the vessel, and is not correlated with branch orifices. Review of the literature suggests that DIT may not be a single process, but may vary in pathogenesis from vessel to vessel and from species to species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Atherosclerosis |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1983 |
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Keywords
- Diffuse intimal thickening
- Primates
- Thoracic aorta
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Pathogenesis of diffuse intimal thickening (DIT) in non-human primate thoracic aortas. / Stout, L. Clarke; Whorton, Elbert B.; Vaghela, Mansukh.
In: Atherosclerosis, Vol. 47, No. 1, 1983, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogenesis of diffuse intimal thickening (DIT) in non-human primate thoracic aortas
AU - Stout, L. Clarke
AU - Whorton, Elbert B.
AU - Vaghela, Mansukh
PY - 1983
Y1 - 1983
N2 - The pathogenesis of diffuse intimal thickening (DIT) is not well understood. In animals, it is positively correlated with size, and with the exception of the pig, is thought to involve the proximal more than the distal portions of vessels. DIT is often not visible grossly, so that it's study requires extensive microscopic sampling of tissue. Review of previous studies in animals suggests that microscopic sampling may not have been sufficient to determine exactly where DIT occurs throughout the entire length of a vessel. The present study is a longitudinal step-serial section examination of the entire descending thoracic aorta from 12 adult non-human primates of varying size and species and with varying degrees of DIT as determined previously by more limited cross-section techniques. The findings indicate that DIT is not more pronounced in the proximal versus the distal segments of the vessel, and is not correlated with branch orifices. Review of the literature suggests that DIT may not be a single process, but may vary in pathogenesis from vessel to vessel and from species to species.
AB - The pathogenesis of diffuse intimal thickening (DIT) is not well understood. In animals, it is positively correlated with size, and with the exception of the pig, is thought to involve the proximal more than the distal portions of vessels. DIT is often not visible grossly, so that it's study requires extensive microscopic sampling of tissue. Review of previous studies in animals suggests that microscopic sampling may not have been sufficient to determine exactly where DIT occurs throughout the entire length of a vessel. The present study is a longitudinal step-serial section examination of the entire descending thoracic aorta from 12 adult non-human primates of varying size and species and with varying degrees of DIT as determined previously by more limited cross-section techniques. The findings indicate that DIT is not more pronounced in the proximal versus the distal segments of the vessel, and is not correlated with branch orifices. Review of the literature suggests that DIT may not be a single process, but may vary in pathogenesis from vessel to vessel and from species to species.
KW - Diffuse intimal thickening
KW - Primates
KW - Thoracic aorta
UR - http://www.scopus.com/inward/record.url?scp=0020620030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020620030&partnerID=8YFLogxK
U2 - 10.1016/0021-9150(83)90065-5
DO - 10.1016/0021-9150(83)90065-5
M3 - Article
VL - 47
SP - 1
EP - 6
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -