Pathogenesis of modoc virus (Flaviviridae; Flavivirus) in persistently infected hamsters

A. Paige Adams, Amelia P.A. Travassos Da Rosa, Marcio R. Nunes, Shu Yuan Xiao, Robert B. Tesh

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The long-term persistence of Modoc virus (MODV) infection was investigated in a hamster model. Golden hamsters (Mesocricetus auratus) were infected by subcutaneous inoculation with MODV, in which fatal encephalitis developed in 12.5% (2 of 16). Surviving hamsters shed infectious MODV in their urine during the first five months after infection, and infectious MODV was recovered by co-cultivation of kidney tissue up to eight months after infection. There were no histopathologic changes observed in the kidneys despite detection of viral antigen for 250 days after infection. Mild inflammation and neuronal degeneration in the central nervous system were the primary lesions observed during early infection. These findings confirm previous reports of persistent flavivirus infection in animals and suggest a mechanism for the maintenance of MODV in nature.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume88
Issue number3
DOIs
StatePublished - Mar 1 2013

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ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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