Pathogenesis of modoc virus (Flaviviridae; Flavivirus) in persistently infected hamsters

A. Paige Adams; Amelia P.A. Travassos Da Rosa; Marcio R. Nunes; Shu Yuan Xiao; Robert B. Tesh

doi:10.4269/ajtmh.12-0110

Pathogenesis of modoc virus (Flaviviridae; Flavivirus) in persistently infected hamsters

A. Paige Adams, Amelia P.A. Travassos Da Rosa, Marcio R. Nunes, Shu Yuan Xiao, Robert B. Tesh

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The long-term persistence of Modoc virus (MODV) infection was investigated in a hamster model. Golden hamsters (Mesocricetus auratus) were infected by subcutaneous inoculation with MODV, in which fatal encephalitis developed in 12.5% (2 of 16). Surviving hamsters shed infectious MODV in their urine during the first five months after infection, and infectious MODV was recovered by co-cultivation of kidney tissue up to eight months after infection. There were no histopathologic changes observed in the kidneys despite detection of viral antigen for 250 days after infection. Mild inflammation and neuronal degeneration in the central nervous system were the primary lesions observed during early infection. These findings confirm previous reports of persistent flavivirus infection in animals and suggest a mechanism for the maintenance of MODV in nature.

Original language	English (US)
Pages (from-to)	455-460
Number of pages	6
Journal	American Journal of Tropical Medicine and Hygiene
Volume	88
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.12-0110
State	Published - Mar 2013
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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abstract = "The long-term persistence of Modoc virus (MODV) infection was investigated in a hamster model. Golden hamsters (Mesocricetus auratus) were infected by subcutaneous inoculation with MODV, in which fatal encephalitis developed in 12.5% (2 of 16). Surviving hamsters shed infectious MODV in their urine during the first five months after infection, and infectious MODV was recovered by co-cultivation of kidney tissue up to eight months after infection. There were no histopathologic changes observed in the kidneys despite detection of viral antigen for 250 days after infection. Mild inflammation and neuronal degeneration in the central nervous system were the primary lesions observed during early infection. These findings confirm previous reports of persistent flavivirus infection in animals and suggest a mechanism for the maintenance of MODV in nature.",

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AU - Adams, A. Paige

AU - Travassos Da Rosa, Amelia P.A.

AU - Nunes, Marcio R.

AU - Xiao, Shu Yuan

AU - Tesh, Robert B.

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AB - The long-term persistence of Modoc virus (MODV) infection was investigated in a hamster model. Golden hamsters (Mesocricetus auratus) were infected by subcutaneous inoculation with MODV, in which fatal encephalitis developed in 12.5% (2 of 16). Surviving hamsters shed infectious MODV in their urine during the first five months after infection, and infectious MODV was recovered by co-cultivation of kidney tissue up to eight months after infection. There were no histopathologic changes observed in the kidneys despite detection of viral antigen for 250 days after infection. Mild inflammation and neuronal degeneration in the central nervous system were the primary lesions observed during early infection. These findings confirm previous reports of persistent flavivirus infection in animals and suggest a mechanism for the maintenance of MODV in nature.

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Pathogenesis of modoc virus (Flaviviridae; Flavivirus) in persistently infected hamsters

Abstract

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