Pathogenesis of rickettsial eschars

The tache noire of boutonneuse fever

David Walker, Cecilia Occhino, Giuseppe R. Tringali, Salvatore Di Rosa, Serafino Mansueto

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Prospective investigation of cutaneous lesions of 24 Sicilian patients revealed that 17 were taches noires from patients with a documented diagnosis of boutonneuse fever. Immunofluorescent Rickettsia conorii were demonstrated in 14 of 17 taches noires. The major pathologic lesions observed were a moderate-to-severe lymphohistiocytic vasculitis (17 of 17 cases), generally moderate dermal edema (17 of 17 cases), and cutaneous necrosis (12 of 16 cases). In contrast with previous observations of eschars in Rocky Mountain spotted fever, thrombosis was usually absent (nine of 17 cases) or inconsequential (five of 17 cases). Thus, it appears that the pathogenic mechanism of the ischemic necrosis is not thrombosis, suggesting either compression of the microcirculation by the dermal edema or another mechanism. Review of the biomedical literature related to eschars and cutaneous arthropod bites strongly argues against a pathogenetic contribution of the tick bite itself other than the intradermal inoculation of rickettsiae. The tache noire offers an excellent, accessible model for the study of the human-rickettsia interaction, including the pathogenic mechanisms leading to necrosis and the immune mechanisms resulting in killing the rickettsiae.

Original languageEnglish (US)
Pages (from-to)1449-1454
Number of pages6
JournalHuman Pathology
Volume19
Issue number12
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Boutonneuse Fever
Rickettsia
Skin
Necrosis
Edema
Thrombosis
Rickettsia conorii
Rocky Mountain Spotted Fever
Tick Bites
Arthropods
Bites and Stings
Microcirculation
Vasculitis

Keywords

  • eschar
  • immunofluorescence
  • rickettsia
  • Rickettsia conorii

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathogenesis of rickettsial eschars : The tache noire of boutonneuse fever. / Walker, David; Occhino, Cecilia; Tringali, Giuseppe R.; Rosa, Salvatore Di; Mansueto, Serafino.

In: Human Pathology, Vol. 19, No. 12, 1988, p. 1449-1454.

Research output: Contribution to journalArticle

Walker, D, Occhino, C, Tringali, GR, Rosa, SD & Mansueto, S 1988, 'Pathogenesis of rickettsial eschars: The tache noire of boutonneuse fever', Human Pathology, vol. 19, no. 12, pp. 1449-1454. https://doi.org/10.1016/S0046-8177(88)80238-7
Walker, David ; Occhino, Cecilia ; Tringali, Giuseppe R. ; Rosa, Salvatore Di ; Mansueto, Serafino. / Pathogenesis of rickettsial eschars : The tache noire of boutonneuse fever. In: Human Pathology. 1988 ; Vol. 19, No. 12. pp. 1449-1454.
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