Pathogenesis-related proteins of plants as allergens

Terumi Midoro-Horiuti, E. G. Brooks, R. M. Goldblum

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objective: Many pathogenesis-related (PR) proteins from plants are allergenic. We review the evidence that PR proteins represent an increasingly important group of plant-derived allergens. Data Sources: A detailed literature search was conducted through PubMed and GenBank databases. Study Selection: All reports in PubMed and GenBank related to PR protein allergens for which at least partial amino acid sequence is known were included. Results: Production of PR proteins by plants is induced in plants by stress. Members of PR-protein groups 2, 3, 4, 5, 8, 10, and 14 have demonstrated allergenicity. PR2-, 3-, 4-, and 8-homologous allergens are represented by the latex allergens. Cross-reactivity of PR3 latex allergen, Hev b 6.02, with some fruit allergens may be a reflection of the representation of homologous PR proteins among varied plants. The expression of one of the representative PR5-homologous cedar pollen allergens, Jun a 3, is highly variable across years and geographic areas, possibly because of variable induction of this PR protein by environmental factors. PR10-homologous birch pollen allergen, Bet v 1, is structurally similar to and cross-reacts with PR10 proteins from fruits (eg, Mal d 1) which cause oral allergy syndrome. PR14 allergens (eg, Zea m 14) consist of lipid transfer proteins found in grains and fruits and are inducers of anaphylaxis. Conclusions: PR-homologous allergens are pervasive in nature. Similarity in the amino acid sequences among members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. Induced expression of PR-homologous allergens by environmental factors may explain varying degrees of allergenicity. Man-made environmental pollutants may also alter the expression of some PR protein allergens.

Original languageEnglish (US)
Pages (from-to)261-271
Number of pages11
JournalAnnals of Allergy, Asthma and Immunology
Volume87
Issue number4
StatePublished - 2001

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Allergens
Proteins
Fruit
Nucleic Acid Databases
Latex
Pollen
PubMed
plant pathogenesis-related proteins
Amino Acid Sequence
Betula
Environmental Pollutants
Information Storage and Retrieval
Anaphylaxis
Zea mays
Hypersensitivity
Databases

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Pathogenesis-related proteins of plants as allergens. / Midoro-Horiuti, Terumi; Brooks, E. G.; Goldblum, R. M.

In: Annals of Allergy, Asthma and Immunology, Vol. 87, No. 4, 2001, p. 261-271.

Research output: Contribution to journalArticle

Midoro-Horiuti, Terumi ; Brooks, E. G. ; Goldblum, R. M. / Pathogenesis-related proteins of plants as allergens. In: Annals of Allergy, Asthma and Immunology. 2001 ; Vol. 87, No. 4. pp. 261-271.
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