Abstract
Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.
| Original language | English (US) |
|---|---|
| Article number | 30916 |
| Journal | Scientific Reports |
| Volume | 6 |
| DOIs | |
| State | Published - Aug 3 2016 |
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ASJC Scopus subject areas
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Cite this
Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates : Implications for Antibody Therapy. / Mire, Chad; Satterfield, Benjamin A.; Geisbert, Joan B.; Agans, Krystle N.; Borisevich, Viktoriya; Yan, Lianying; Chan, Yee Peng; Cross, Robert; Fenton, Karla A.; Broder, Christopher C.; Geisbert, Thomas.
In: Scientific Reports, Vol. 6, 30916, 03.08.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates
T2 - Implications for Antibody Therapy
AU - Mire, Chad
AU - Satterfield, Benjamin A.
AU - Geisbert, Joan B.
AU - Agans, Krystle N.
AU - Borisevich, Viktoriya
AU - Yan, Lianying
AU - Chan, Yee Peng
AU - Cross, Robert
AU - Fenton, Karla A.
AU - Broder, Christopher C.
AU - Geisbert, Thomas
PY - 2016/8/3
Y1 - 2016/8/3
N2 - Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.
AB - Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.
UR - http://www.scopus.com/inward/record.url?scp=84981710203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981710203&partnerID=8YFLogxK
U2 - 10.1038/srep30916
DO - 10.1038/srep30916
M3 - Article
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 30916
ER -