@article{a4365f62c671413dae1545fd06e4acb7,
title = "Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy",
abstract = "Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.",
author = "Mire, {Chad E.} and Satterfield, {Benjamin A.} and Geisbert, {Joan B.} and Agans, {Krystle N.} and Viktoriya Borisevich and Lianying Yan and Chan, {Yee Peng} and Cross, {Robert W.} and Fenton, {Karla A.} and Broder, {Christopher C.} and Geisbert, {Thomas W.}",
note = "Funding Information: We thank Daniel Deer for technical assistance and the staff of the UTMB Animal Resources Center for animal husbandry, and the UTMB Research Histopathology Core for assistance with tissue processing. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the University of Texas Medical Branch, the U.S. Army, or the National Institutes of Health. This study was supported by the Department of Health and Human Services, National Institutes of Health, grants AI082121 to TWG and AI054715 and AI077995 to CCB and in part by the Intramural Research Program of the NIAID, NIH. Publisher Copyright: {\textcopyright} The Author(s) 2016.",
year = "2016",
month = aug,
day = "3",
doi = "10.1038/srep30916",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}