Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Chad Mire, Benjamin A. Satterfield, Joan B. Geisbert, Krystle N. Agans, Viktoriya Borisevich, Lianying Yan, Yee Peng Chan, Robert Cross, Karla A. Fenton, Christopher C. Broder, Thomas Geisbert

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.

Original languageEnglish (US)
Article number30916
JournalScientific Reports
Volume6
DOIs
StatePublished - Aug 3 2016

Fingerprint

Nipah Virus
Bangladesh
Malaysia
Primates
Antibodies
Therapeutics
Cercopithecus aethiops

ASJC Scopus subject areas

  • General

Cite this

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates : Implications for Antibody Therapy. / Mire, Chad; Satterfield, Benjamin A.; Geisbert, Joan B.; Agans, Krystle N.; Borisevich, Viktoriya; Yan, Lianying; Chan, Yee Peng; Cross, Robert; Fenton, Karla A.; Broder, Christopher C.; Geisbert, Thomas.

In: Scientific Reports, Vol. 6, 30916, 03.08.2016.

Research output: Contribution to journalArticle

Mire, Chad ; Satterfield, Benjamin A. ; Geisbert, Joan B. ; Agans, Krystle N. ; Borisevich, Viktoriya ; Yan, Lianying ; Chan, Yee Peng ; Cross, Robert ; Fenton, Karla A. ; Broder, Christopher C. ; Geisbert, Thomas. / Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates : Implications for Antibody Therapy. In: Scientific Reports. 2016 ; Vol. 6.
@article{a4365f62c671413dae1545fd06e4acb7,
title = "Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy",
abstract = "Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50{\%} of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.",
author = "Chad Mire and Satterfield, {Benjamin A.} and Geisbert, {Joan B.} and Agans, {Krystle N.} and Viktoriya Borisevich and Lianying Yan and Chan, {Yee Peng} and Robert Cross and Fenton, {Karla A.} and Broder, {Christopher C.} and Thomas Geisbert",
year = "2016",
month = "8",
day = "3",
doi = "10.1038/srep30916",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates

T2 - Implications for Antibody Therapy

AU - Mire, Chad

AU - Satterfield, Benjamin A.

AU - Geisbert, Joan B.

AU - Agans, Krystle N.

AU - Borisevich, Viktoriya

AU - Yan, Lianying

AU - Chan, Yee Peng

AU - Cross, Robert

AU - Fenton, Karla A.

AU - Broder, Christopher C.

AU - Geisbert, Thomas

PY - 2016/8/3

Y1 - 2016/8/3

N2 - Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.

AB - Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiV M) and Bangladesh (NiV B). Differences in transmission patterns and mortality rates suggest that NiV B may be more pathogenic than NiV M. To investigate pathogenic differences between strains, 4 African green monkeys (AGM) were exposed to NiV M and 4 AGMs were exposed to NiV B. While NiV B was uniformly lethal, only 50% of NiV M -infected animals succumbed to infection. Histopathology of lungs and spleens from NiV B -infected AGMs was significantly more severe than NiV M -infected animals. Importantly, a second study utilizing 11 AGMs showed that the therapeutic window for human monoclonal antibody m102.4, previously shown to rescue AGMs from NiV M infection, was much shorter in NiV B -infected AGMs. Together, these data show that NiV B is more pathogenic in AGMs under identical experimental conditions and suggests that postexposure treatments may need to be NiV strain specific for optimal efficacy.

UR - http://www.scopus.com/inward/record.url?scp=84981710203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981710203&partnerID=8YFLogxK

U2 - 10.1038/srep30916

DO - 10.1038/srep30916

M3 - Article

C2 - 27484128

AN - SCOPUS:84981710203

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 30916

ER -