Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus

Thomas Larsen, Edward L. Stevens, Kelly J. Davis, Joan B. Geisbert, Kathleen M. Daddario-DiCaprio, Peter B. Jahrling, Lisa E. Hensley, Thomas Geisbert

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Zaire Ebola virus infection in macaques causes a fatal disease with a pathogenesis similar to that in humans. During several independent therapy studies, we noted altered tissue tropism in 6 rhesus macaques that survived longer than those with a typical disease course. The mean time to death for these 6 macaques was 21.7 days, which is significantly longer than the average mean time to death of 8.3 days for 20 untreated historical control animals. In addition to living significantly longer, these 6 animals exhibited a variety of deteriorating clinical signs with pathologic findings that were not seen in the untreated control animals, as well as the presence of viral antigen in the brain, eye, pancreas, thyroid, and lung. We suggest that treatment extended the time course of the disease and permitted the virus to infect tissues not usually affected in the typical model.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume196
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 15 2007
Externally publishedYes

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Ebolavirus
Primates
Macaca
Ebola Hemorrhagic Fever
Tropism
Viral Antigens
Virus Diseases
Macaca mulatta
Pancreas
Thyroid Gland
Lung
Brain
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus. / Larsen, Thomas; Stevens, Edward L.; Davis, Kelly J.; Geisbert, Joan B.; Daddario-DiCaprio, Kathleen M.; Jahrling, Peter B.; Hensley, Lisa E.; Geisbert, Thomas.

In: Journal of Infectious Diseases, Vol. 196, No. SUPPL. 2, 15.11.2007.

Research output: Contribution to journalArticle

Larsen, T, Stevens, EL, Davis, KJ, Geisbert, JB, Daddario-DiCaprio, KM, Jahrling, PB, Hensley, LE & Geisbert, T 2007, 'Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus', Journal of Infectious Diseases, vol. 196, no. SUPPL. 2. https://doi.org/10.1086/520589
Larsen, Thomas ; Stevens, Edward L. ; Davis, Kelly J. ; Geisbert, Joan B. ; Daddario-DiCaprio, Kathleen M. ; Jahrling, Peter B. ; Hensley, Lisa E. ; Geisbert, Thomas. / Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus. In: Journal of Infectious Diseases. 2007 ; Vol. 196, No. SUPPL. 2.
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