Pathological and virological features of arenavirus disease in guinea pigs

Comparison of two Pichinde virus strains

Judith Aronson, Norbert K. Herzog, Thomas R. Jerrells

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

A guinea pig passage-adapted strain of the arenavirus Pichinde (adPIC) is highly virulent in inbred guinea pigs, whereas the related strain PIC3739 is attenuated. Both viruses were macrophage tropic and infected peritoneal, splenic, liver, and alveolar macrophages during experimental Pichinde virus infection. Infection with the virulent strain was associated with unlimited viral replication in the face of exaggerated delayed-type hypersensitivity response, manifested by the macrophage disappearance reaction. Histopathological lesions unique to adPIC-infected guinea pigs included intestinal villus blunting with mucosal infiltration by pyknotic debris- laden macrophages and apoptosis of crypt epithelial cells. Splenic red pulp necrosis was also significantly associated with adPIC infection but not PIC3739 infection. These findings may provide clues to the pathogenesis of a group of poorly understood human viral hemorrhagic fevers.

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalAmerican Journal of Pathology
Volume145
Issue number1
StatePublished - Jul 1994

Fingerprint

Pichinde virus
Arenavirus
Guinea Pigs
Macrophages
Dental Pulp Necrosis
Viral Hemorrhagic Fevers
Infection
Alveolar Macrophages
Delayed Hypersensitivity
Virus Diseases
Epithelial Cells
Apoptosis
Viruses
Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathological and virological features of arenavirus disease in guinea pigs : Comparison of two Pichinde virus strains. / Aronson, Judith; Herzog, Norbert K.; Jerrells, Thomas R.

In: American Journal of Pathology, Vol. 145, No. 1, 07.1994, p. 228-235.

Research output: Contribution to journalArticle

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