Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus

Tomoharu Suzuki; Marina Hosotani Saito; Nantian Lin; Atsushi Tamura; Nadezhda Yun; Takaaki Koma; Junki Maruyama; Slobodan Paessler; Tomoko Makishima

doi:10.1093/infdis/jiae516

Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus

Tomoharu Suzuki, Marina Hosotani Saito, Nantian Lin, Atsushi Tamura, Nadezhda Yun, Takaaki Koma, Junki Maruyama, Slobodan Paessler, Tomoko Makishima

Research output: Contribution to journal › Article › peer-review

Abstract

Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.

Original language	English (US)
Pages (from-to)	1074-1078
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	231
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiae516
State	Published - Apr 15 2025
Externally published	Yes

Keywords

Lassa fever
Lassa virus
inner ear
pathology
vestibular apparatus

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiae516

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title = "Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus",

abstract = "Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.",

keywords = "Lassa fever, Lassa virus, inner ear, pathology, vestibular apparatus",

author = "Tomoharu Suzuki and Saito, \{Marina Hosotani\} and Nantian Lin and Atsushi Tamura and Nadezhda Yun and Takaaki Koma and Junki Maruyama and Slobodan Paessler and Tomoko Makishima",

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doi = "10.1093/infdis/jiae516",

language = "English (US)",

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journal = "Journal of Infectious Diseases",

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T1 - Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice

T2 - Histopathological Analysis of the Inner Ear Vestibular Apparatus

AU - Suzuki, Tomoharu

AU - Saito, Marina Hosotani

AU - Lin, Nantian

AU - Tamura, Atsushi

AU - Yun, Nadezhda

AU - Koma, Takaaki

AU - Maruyama, Junki

AU - Paessler, Slobodan

AU - Makishima, Tomoko

PY - 2025/4/15

Y1 - 2025/4/15

N2 - Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.

AB - Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.

KW - Lassa fever

KW - Lassa virus

KW - inner ear

KW - pathology

KW - vestibular apparatus

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Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus

Abstract

Keywords

ASJC Scopus subject areas

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