Pathology of experimental Ebola virus infection in African green monkeys: Involvement of fibroblastic reticular cells

Kelly J. Davis, Arthur O. Anderson, Thomas Geisbert, Keith E. Steele, Joan B. Geisbert, Peter Vogel, Brett M. Connolly, John W. Huggins, Peter B. Jahrling, Nancy K. Jaax

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background. - Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells. Objective. - To examine the distribution of lesions and Ebola virus antigen in the tissues of six adult male African green monkeys (Cercopithecus aethiops) that died 6 to 7 days after intraperitoneal inoculation of Ebola-Zaire (Mayinga) virus. Methods. - Tissues were examined histologically, immunohistochemically, and ultrastructurally. Results. - A major novel finding of this study was that fibroblastic reticular cells were immunohistochemically and ultrastructurally identified as targets of Ebola virus infection. Conclusions. - The role of Ebola virus-infected fibroblastic reticular cells in the pathogenesis of Ebola hemorrhagic fever warrants further investigation. This is especially important because of recent observations indicating that fibroblastic reticular cells, along with the reticular fibers they produce, maximize the efficiency of the immune response.

Original languageEnglish (US)
Pages (from-to)805-819
Number of pages15
JournalArchives of Pathology and Laboratory Medicine
Volume121
Issue number8
StatePublished - 1997
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Ebolavirus
Cercopithecus aethiops
Pathology
Reticulin
Mononuclear Phagocyte System
Primates
Disease Outbreaks
Fever
Endothelial Cells
Antigens

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Davis, K. J., Anderson, A. O., Geisbert, T., Steele, K. E., Geisbert, J. B., Vogel, P., ... Jaax, N. K. (1997). Pathology of experimental Ebola virus infection in African green monkeys: Involvement of fibroblastic reticular cells. Archives of Pathology and Laboratory Medicine, 121(8), 805-819.

Pathology of experimental Ebola virus infection in African green monkeys : Involvement of fibroblastic reticular cells. / Davis, Kelly J.; Anderson, Arthur O.; Geisbert, Thomas; Steele, Keith E.; Geisbert, Joan B.; Vogel, Peter; Connolly, Brett M.; Huggins, John W.; Jahrling, Peter B.; Jaax, Nancy K.

In: Archives of Pathology and Laboratory Medicine, Vol. 121, No. 8, 1997, p. 805-819.

Research output: Contribution to journalArticle

Davis, KJ, Anderson, AO, Geisbert, T, Steele, KE, Geisbert, JB, Vogel, P, Connolly, BM, Huggins, JW, Jahrling, PB & Jaax, NK 1997, 'Pathology of experimental Ebola virus infection in African green monkeys: Involvement of fibroblastic reticular cells', Archives of Pathology and Laboratory Medicine, vol. 121, no. 8, pp. 805-819.
Davis, Kelly J. ; Anderson, Arthur O. ; Geisbert, Thomas ; Steele, Keith E. ; Geisbert, Joan B. ; Vogel, Peter ; Connolly, Brett M. ; Huggins, John W. ; Jahrling, Peter B. ; Jaax, Nancy K. / Pathology of experimental Ebola virus infection in African green monkeys : Involvement of fibroblastic reticular cells. In: Archives of Pathology and Laboratory Medicine. 1997 ; Vol. 121, No. 8. pp. 805-819.
@article{fec738d957214365a617ecac31bd8576,
title = "Pathology of experimental Ebola virus infection in African green monkeys: Involvement of fibroblastic reticular cells",
abstract = "Background. - Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells. Objective. - To examine the distribution of lesions and Ebola virus antigen in the tissues of six adult male African green monkeys (Cercopithecus aethiops) that died 6 to 7 days after intraperitoneal inoculation of Ebola-Zaire (Mayinga) virus. Methods. - Tissues were examined histologically, immunohistochemically, and ultrastructurally. Results. - A major novel finding of this study was that fibroblastic reticular cells were immunohistochemically and ultrastructurally identified as targets of Ebola virus infection. Conclusions. - The role of Ebola virus-infected fibroblastic reticular cells in the pathogenesis of Ebola hemorrhagic fever warrants further investigation. This is especially important because of recent observations indicating that fibroblastic reticular cells, along with the reticular fibers they produce, maximize the efficiency of the immune response.",
author = "Davis, {Kelly J.} and Anderson, {Arthur O.} and Thomas Geisbert and Steele, {Keith E.} and Geisbert, {Joan B.} and Peter Vogel and Connolly, {Brett M.} and Huggins, {John W.} and Jahrling, {Peter B.} and Jaax, {Nancy K.}",
year = "1997",
language = "English (US)",
volume = "121",
pages = "805--819",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "8",

}

TY - JOUR

T1 - Pathology of experimental Ebola virus infection in African green monkeys

T2 - Involvement of fibroblastic reticular cells

AU - Davis, Kelly J.

AU - Anderson, Arthur O.

AU - Geisbert, Thomas

AU - Steele, Keith E.

AU - Geisbert, Joan B.

AU - Vogel, Peter

AU - Connolly, Brett M.

AU - Huggins, John W.

AU - Jahrling, Peter B.

AU - Jaax, Nancy K.

PY - 1997

Y1 - 1997

N2 - Background. - Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells. Objective. - To examine the distribution of lesions and Ebola virus antigen in the tissues of six adult male African green monkeys (Cercopithecus aethiops) that died 6 to 7 days after intraperitoneal inoculation of Ebola-Zaire (Mayinga) virus. Methods. - Tissues were examined histologically, immunohistochemically, and ultrastructurally. Results. - A major novel finding of this study was that fibroblastic reticular cells were immunohistochemically and ultrastructurally identified as targets of Ebola virus infection. Conclusions. - The role of Ebola virus-infected fibroblastic reticular cells in the pathogenesis of Ebola hemorrhagic fever warrants further investigation. This is especially important because of recent observations indicating that fibroblastic reticular cells, along with the reticular fibers they produce, maximize the efficiency of the immune response.

AB - Background. - Ebola virus has been responsible for explosive lethal outbreaks of hemorrhagic fever in both humans and nonhuman primates. Previous studies showed a predilection of Ebola virus for cells of the mononuclear phagocyte system and endothelial cells. Objective. - To examine the distribution of lesions and Ebola virus antigen in the tissues of six adult male African green monkeys (Cercopithecus aethiops) that died 6 to 7 days after intraperitoneal inoculation of Ebola-Zaire (Mayinga) virus. Methods. - Tissues were examined histologically, immunohistochemically, and ultrastructurally. Results. - A major novel finding of this study was that fibroblastic reticular cells were immunohistochemically and ultrastructurally identified as targets of Ebola virus infection. Conclusions. - The role of Ebola virus-infected fibroblastic reticular cells in the pathogenesis of Ebola hemorrhagic fever warrants further investigation. This is especially important because of recent observations indicating that fibroblastic reticular cells, along with the reticular fibers they produce, maximize the efficiency of the immune response.

UR - http://www.scopus.com/inward/record.url?scp=0030835420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030835420&partnerID=8YFLogxK

M3 - Article

C2 - 9278608

AN - SCOPUS:0030835420

VL - 121

SP - 805

EP - 819

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 8

ER -