Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus)

C. M. Keenan, S. M. Lemon, James LeDuc, G. A. McNamee, L. N. Binn

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis A virus (HM-175 or PA-33) were examined for histopathologic alterations. Preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts and hepatic lobular parenchyma. Histopathologic features that were present in biopsies taken during the period of elevated serum alanine aminotransferase activity (16-43 days after the intravenous inoculation of virus) included infiltration of predominantly mononuclear inflammatory cells into portal tracts and surrounding parenchyma, degeneration and necrosis of hepatocytes, and hypertrophy of Kupffer cells. Changes were similar in monkeys infected with either HM-175 or PA-33 virus strains. Convalescent biopsies (147-186 days after inoculation) showed resolving lesions with mild portal inflammation and occasional focal collections of inflammatory cells in the parenchyma. These histologic changes are similar to those associated with hepatitis A infection in man, chimpanzees, and several species of marmosets, and support the further use of the owl monkey as a model of human hepatitis A.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAmerican Journal of Pathology
Volume115
Issue number1
StatePublished - 1984
Externally publishedYes

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Aotus trivirgatus
Aotidae
Hepatitis A
Pathology
Biopsy
Infection
Viruses
Hepatitis A virus
Callithrix
Kupffer Cells
Pan troglodytes
Liver
Alanine Transaminase
Hypertrophy
Haplorhini
Hepatocytes
Necrosis
Inflammation
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Keenan, C. M., Lemon, S. M., LeDuc, J., McNamee, G. A., & Binn, L. N. (1984). Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). American Journal of Pathology, 115(1), 1-8.

Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). / Keenan, C. M.; Lemon, S. M.; LeDuc, James; McNamee, G. A.; Binn, L. N.

In: American Journal of Pathology, Vol. 115, No. 1, 1984, p. 1-8.

Research output: Contribution to journalArticle

Keenan, CM, Lemon, SM, LeDuc, J, McNamee, GA & Binn, LN 1984, 'Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus)', American Journal of Pathology, vol. 115, no. 1, pp. 1-8.
Keenan, C. M. ; Lemon, S. M. ; LeDuc, James ; McNamee, G. A. ; Binn, L. N. / Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). In: American Journal of Pathology. 1984 ; Vol. 115, No. 1. pp. 1-8.
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