Pathology of whitewater Arroyo viral infection in the white-thorated woodrat (Neotoma albigula)

S. M. Lele, M. L. Milazzo, K. Graves, Judith Aronson, A. B. West, C. F. Fulhorst

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The white-throated woodrat is a principal host of Whitewater Arroyo (WWA) virus, an arenavirus, in the western United States. The purpose of the present study was to investigate the pathology of WWA infection in this species. Twenty-one animals (eight newborn, seven juvenile, and six adult) were inoculated with WWA virus and killed at varying intervals after inoculation. The most striking histological findings were lymphocytic meningitis and perivascular lymphocytic cuffing in the brains of the animals killed on day 85, 113 or 121. Arenaviral antigen was detected inimunohistochemically in the brain of each affected animal, suggesting that the inflammatory lesions in the brain were caused by WWA virus. Comparisons of the results of tests for infectious virus and antigen in brain and other solid tissues indicated that immunohistochemistry may be a useful method for detection of WWA viral antigen in post-mortem specimens.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalJournal of Comparative Pathology
Volume128
Issue number4
DOIs
StatePublished - May 2003

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Sigmodontinae
Neotoma
Virus Diseases
Pathology
Viruses
brain
viruses
Brain
infection
Arenavirus
antigens
Newborn Animals
Antigens
Viral Antigens
viral antigens
meningitis
Western United States
Meningitis
lesions (animal)
immunohistochemistry

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Pathology of whitewater Arroyo viral infection in the white-thorated woodrat (Neotoma albigula). / Lele, S. M.; Milazzo, M. L.; Graves, K.; Aronson, Judith; West, A. B.; Fulhorst, C. F.

In: Journal of Comparative Pathology, Vol. 128, No. 4, 05.2003, p. 289-292.

Research output: Contribution to journalArticle

Lele, S. M. ; Milazzo, M. L. ; Graves, K. ; Aronson, Judith ; West, A. B. ; Fulhorst, C. F. / Pathology of whitewater Arroyo viral infection in the white-thorated woodrat (Neotoma albigula). In: Journal of Comparative Pathology. 2003 ; Vol. 128, No. 4. pp. 289-292.
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