Pathomechanisms of myocardial dysfunction in sepsis

Clara Batista Lorigados, Francisco Garcia Soriano, Csaba Szabo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Sepsis remains one of the leading causes of death in intensive care units. Progressive cardiovascular failure is an important cause of the mortality. Septic patients with myocardial dysfunction have significantly higher mortality compared with patients without cardiovascular impairment. Myocardial dysfunction in sepsis is characterized by decreased contractility and impaired myocardial compliance. Experimental studies of sepsis showed heterogeneity of microvascular perfusion, as well as impaired myocardial oxygen extraction. The underlying cellular mechanisms include increased neutrophil adhesion to the endothelium, production of reactive free radicals and oxidants, and endothelial dysfunction. Superoxide, nitric oxide and peroxynitrite cardiac formation has been demonstrated in septic hearts, which has been implicated in the pathogenesis of the myocardial depression and cell death in sepsis. Nitric oxide, carbon monoxide and hydrogen sulfide are gaseotransmitters that may exert protective effects in the septic heart.

Original languageEnglish (US)
Pages (from-to)274-284
Number of pages11
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Volume10
Issue number3
StatePublished - 2010

Fingerprint

Sepsis
Nitric Oxide
Hydrogen Sulfide
Peroxynitrous Acid
Mortality
Carbon Monoxide
Oxidants
Superoxides
Compliance
Free Radicals
Endothelium
Intensive Care Units
Cause of Death
Neutrophils
Cell Death
Perfusion
Oxygen

Keywords

  • Carbon monoxide
  • Heart
  • Hydrogen sulfide
  • Myocardial depression
  • Nitric oxide
  • Peroxynitrite
  • Sepsis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

Pathomechanisms of myocardial dysfunction in sepsis. / Lorigados, Clara Batista; Soriano, Francisco Garcia; Szabo, Csaba.

In: Endocrine, Metabolic and Immune Disorders - Drug Targets, Vol. 10, No. 3, 2010, p. 274-284.

Research output: Contribution to journalArticle

Lorigados, Clara Batista ; Soriano, Francisco Garcia ; Szabo, Csaba. / Pathomechanisms of myocardial dysfunction in sepsis. In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 2010 ; Vol. 10, No. 3. pp. 274-284.
@article{bd547e47379f47c1ae04a8bdffe59e8b,
title = "Pathomechanisms of myocardial dysfunction in sepsis",
abstract = "Sepsis remains one of the leading causes of death in intensive care units. Progressive cardiovascular failure is an important cause of the mortality. Septic patients with myocardial dysfunction have significantly higher mortality compared with patients without cardiovascular impairment. Myocardial dysfunction in sepsis is characterized by decreased contractility and impaired myocardial compliance. Experimental studies of sepsis showed heterogeneity of microvascular perfusion, as well as impaired myocardial oxygen extraction. The underlying cellular mechanisms include increased neutrophil adhesion to the endothelium, production of reactive free radicals and oxidants, and endothelial dysfunction. Superoxide, nitric oxide and peroxynitrite cardiac formation has been demonstrated in septic hearts, which has been implicated in the pathogenesis of the myocardial depression and cell death in sepsis. Nitric oxide, carbon monoxide and hydrogen sulfide are gaseotransmitters that may exert protective effects in the septic heart.",
keywords = "Carbon monoxide, Heart, Hydrogen sulfide, Myocardial depression, Nitric oxide, Peroxynitrite, Sepsis",
author = "Lorigados, {Clara Batista} and Soriano, {Francisco Garcia} and Csaba Szabo",
year = "2010",
language = "English (US)",
volume = "10",
pages = "274--284",
journal = "Endocrine, Metabolic and Immune Disorders - Drug Targets",
issn = "1871-5303",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Pathomechanisms of myocardial dysfunction in sepsis

AU - Lorigados, Clara Batista

AU - Soriano, Francisco Garcia

AU - Szabo, Csaba

PY - 2010

Y1 - 2010

N2 - Sepsis remains one of the leading causes of death in intensive care units. Progressive cardiovascular failure is an important cause of the mortality. Septic patients with myocardial dysfunction have significantly higher mortality compared with patients without cardiovascular impairment. Myocardial dysfunction in sepsis is characterized by decreased contractility and impaired myocardial compliance. Experimental studies of sepsis showed heterogeneity of microvascular perfusion, as well as impaired myocardial oxygen extraction. The underlying cellular mechanisms include increased neutrophil adhesion to the endothelium, production of reactive free radicals and oxidants, and endothelial dysfunction. Superoxide, nitric oxide and peroxynitrite cardiac formation has been demonstrated in septic hearts, which has been implicated in the pathogenesis of the myocardial depression and cell death in sepsis. Nitric oxide, carbon monoxide and hydrogen sulfide are gaseotransmitters that may exert protective effects in the septic heart.

AB - Sepsis remains one of the leading causes of death in intensive care units. Progressive cardiovascular failure is an important cause of the mortality. Septic patients with myocardial dysfunction have significantly higher mortality compared with patients without cardiovascular impairment. Myocardial dysfunction in sepsis is characterized by decreased contractility and impaired myocardial compliance. Experimental studies of sepsis showed heterogeneity of microvascular perfusion, as well as impaired myocardial oxygen extraction. The underlying cellular mechanisms include increased neutrophil adhesion to the endothelium, production of reactive free radicals and oxidants, and endothelial dysfunction. Superoxide, nitric oxide and peroxynitrite cardiac formation has been demonstrated in septic hearts, which has been implicated in the pathogenesis of the myocardial depression and cell death in sepsis. Nitric oxide, carbon monoxide and hydrogen sulfide are gaseotransmitters that may exert protective effects in the septic heart.

KW - Carbon monoxide

KW - Heart

KW - Hydrogen sulfide

KW - Myocardial depression

KW - Nitric oxide

KW - Peroxynitrite

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=78649299966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649299966&partnerID=8YFLogxK

M3 - Article

C2 - 20509838

AN - SCOPUS:78649299966

VL - 10

SP - 274

EP - 284

JO - Endocrine, Metabolic and Immune Disorders - Drug Targets

JF - Endocrine, Metabolic and Immune Disorders - Drug Targets

SN - 1871-5303

IS - 3

ER -