Abstract
Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed little in recent decades. The formation of reactive oxygen and nitrogen species, as well as the procoagulant and antifibrinolytic imbalance of alveolar homeostasis, all play a central role in the pathogenesis of smoke inhalation injury. Further hallmarks include massive airway obstruction owing to cast formation, bronchospasm, the increase in bronchial circulation and transvascular fluid flux. Therefore, anticoagulants, antioxidants and bronchodilators, especially when administered as an aerosol, represent the most promising treatment strategies. The purpose of this review article is to provide an overview of the pathophysiological changes, management and treatment options of smoke inhalation injury based on the current literature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-297 |
| Number of pages | 15 |
| Journal | Expert Review of Respiratory Medicine |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2009 |
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Keywords
- β -agonists
- Acute lung injury
- Anticoagulants
- Antioxidants
- Carbon monoxide
- Cyanide
- Nitric oxide
- Reactive oxygen species
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Immunology and Allergy
- Public Health, Environmental and Occupational Health
Cite this
Pathophysiology, management and treatment of smoke inhalation injury. / Rehberg, Sebastian; Maybauer, Marc O.; Enkhbaatar, Perenlei; Maybauer, Dirk M.; Yamamoto, Yusuke; Traber, Daniel L.
In: Expert Review of Respiratory Medicine, Vol. 3, No. 3, 2009, p. 283-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology, management and treatment of smoke inhalation injury
AU - Rehberg, Sebastian
AU - Maybauer, Marc O.
AU - Enkhbaatar, Perenlei
AU - Maybauer, Dirk M.
AU - Yamamoto, Yusuke
AU - Traber, Daniel L.
PY - 2009
Y1 - 2009
N2 - Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed little in recent decades. The formation of reactive oxygen and nitrogen species, as well as the procoagulant and antifibrinolytic imbalance of alveolar homeostasis, all play a central role in the pathogenesis of smoke inhalation injury. Further hallmarks include massive airway obstruction owing to cast formation, bronchospasm, the increase in bronchial circulation and transvascular fluid flux. Therefore, anticoagulants, antioxidants and bronchodilators, especially when administered as an aerosol, represent the most promising treatment strategies. The purpose of this review article is to provide an overview of the pathophysiological changes, management and treatment options of smoke inhalation injury based on the current literature.
AB - Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed little in recent decades. The formation of reactive oxygen and nitrogen species, as well as the procoagulant and antifibrinolytic imbalance of alveolar homeostasis, all play a central role in the pathogenesis of smoke inhalation injury. Further hallmarks include massive airway obstruction owing to cast formation, bronchospasm, the increase in bronchial circulation and transvascular fluid flux. Therefore, anticoagulants, antioxidants and bronchodilators, especially when administered as an aerosol, represent the most promising treatment strategies. The purpose of this review article is to provide an overview of the pathophysiological changes, management and treatment options of smoke inhalation injury based on the current literature.
KW - β -agonists
KW - Acute lung injury
KW - Anticoagulants
KW - Antioxidants
KW - Carbon monoxide
KW - Cyanide
KW - Nitric oxide
KW - Reactive oxygen species
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UR - http://www.scopus.com/inward/citedby.url?scp=70049096501&partnerID=8YFLogxK
U2 - 10.1586/ers.09.21
DO - 10.1586/ers.09.21
M3 - Article
AN - SCOPUS:70049096501
VL - 3
SP - 283
EP - 297
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 3
ER -