Pathophysiology of lung injury in combined burn and inhalation injury

Perenlei Enkhbaatar, Daniel L. Traber

Research output: Contribution to journalReview article

139 Scopus citations

Abstract

In the U.S.A., more than 1 million burn injuries occur every year. Although the survival from burn injury has increased in recent years with the development of effective fluid resuscitation management and early surgical excision of burned tissue, the mortality of burn injury is still high. In these fire victims, progressive pulmonary failure and cardiovascular dysfunction are important determinants of morbidity and mortality. The morbidity and mortality increases when burn injury is associated with smoke inhalation. In the present review, we will describe the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalClinical Science
Volume107
Issue number2
DOIs
StatePublished - Aug 1 2004

Keywords

  • Acute lung injury
  • Burn and smoke inhalation
  • Cytokine
  • Nitric oxide (NO)
  • Pathophysiology
  • Poly(ADP-ribose) polymerase (PARP)

ASJC Scopus subject areas

  • Medicine(all)

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