Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation

J. B. Zwischenberger, C. S. Cox, P. K. Minifee, D. L. Traber, L. D. Traber, J. T. Flynn, H. A. Linares, David Herndon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

An ovine model was used to study the pathophysiology of smoke inhalation injury treated with extracorporeal membrane oxygenation (ECMO). Smoke inhalation is characterized by leukocyte-oxygen free-radical mediated acute lung injury. Treatment with ECMO was by extracorporeal venoarterial or venovenous perfusion using a venous drainage reservoir, roller pump, heat exchanger, and membrane lung oxygenator capable of oxygen delivery to and carbon dioxide removal from a patient. Blood-foreign surface interactions are known to occur during ECMO. We examined the effects of ECMO on circulating leukocytes, oxygen free-radical activity, thromboxane release, and gas exchange after smoke inhalation injury. Animals treated with smoke and ECMO had significantly increased circulating thromboxane B2 levels and oxygen free-radical activity compared with sham-treated animals and animals treated with smoke and mechanical ventilation (MV). Likewise, there was a significant increase in lung wet-to-dry weight ratios in animals treated with smoke and ECMO compared with those treated with smoke and MV. These data may account for the initial deterioration in native lung function after the initiation of ECMO and imply that ECMO may potentiate the pathophysiology of smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)1582-1586
Number of pages5
JournalChest
Volume103
Issue number5
StatePublished - 1993
Externally publishedYes

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Smoke Inhalation Injury
Extracorporeal Membrane Oxygenation
Sheep
Smoke
Free Radicals
Reactive Oxygen Species
Artificial Respiration
Leukocytes
Membrane Oxygenators
Vascular Access Devices
Lung
Thromboxane B2
Acute Lung Injury
Thromboxanes
Pulmonary Edema
Carbon Dioxide
Inhalation
Drainage
Perfusion
Hot Temperature

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Zwischenberger, J. B., Cox, C. S., Minifee, P. K., Traber, D. L., Traber, L. D., Flynn, J. T., ... Herndon, D. (1993). Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation. Chest, 103(5), 1582-1586.

Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation. / Zwischenberger, J. B.; Cox, C. S.; Minifee, P. K.; Traber, D. L.; Traber, L. D.; Flynn, J. T.; Linares, H. A.; Herndon, David.

In: Chest, Vol. 103, No. 5, 1993, p. 1582-1586.

Research output: Contribution to journalArticle

Zwischenberger, JB, Cox, CS, Minifee, PK, Traber, DL, Traber, LD, Flynn, JT, Linares, HA & Herndon, D 1993, 'Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation', Chest, vol. 103, no. 5, pp. 1582-1586.
Zwischenberger JB, Cox CS, Minifee PK, Traber DL, Traber LD, Flynn JT et al. Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation. Chest. 1993;103(5):1582-1586.
Zwischenberger, J. B. ; Cox, C. S. ; Minifee, P. K. ; Traber, D. L. ; Traber, L. D. ; Flynn, J. T. ; Linares, H. A. ; Herndon, David. / Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation. In: Chest. 1993 ; Vol. 103, No. 5. pp. 1582-1586.
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