Pathophysiology, research challenges, and clinical management of smoke inhalation injury

Perenlei Enkhbaatar, Basil A. Pruitt, Oscar Suman, Ronald Mlcak, Steven Wolf, Hiroyuki Sakurai, David Herndon

Research output: Contribution to journalReview article

27 Scopus citations


Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.

Original languageEnglish (US)
Pages (from-to)1437-1446
Number of pages10
JournalThe Lancet
Issue number10052
StatePublished - Oct 1 2016


ASJC Scopus subject areas

  • Medicine(all)

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