TY - JOUR
T1 - Pathophysiology, research challenges, and clinical management of smoke inhalation injury
AU - Enkhbaatar, Perenlei
AU - Pruitt, Basil A.
AU - Suman, Oscar
AU - Mlcak, Ronald
AU - Wolf, Steven E.
AU - Sakurai, Hiroyuki
AU - Herndon, David N.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.
AB - Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.
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U2 - 10.1016/S0140-6736(16)31458-1
DO - 10.1016/S0140-6736(16)31458-1
M3 - Review article
C2 - 27707500
AN - SCOPUS:84994881892
SN - 0140-6736
VL - 388
SP - 1437
EP - 1446
JO - The Lancet
JF - The Lancet
IS - 10052
ER -