Patients with generalised epilepsy have a higher white blood cell count than patients with focal epilepsy

Rani A. Sarkis, Lara Jehi, Diosely Silveira, Damir Janigro, Imad Najm

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background. Immunological alterations have been noted following seizures in the acute period, however little is known about the effect of type and severity of epilepsy on leukocyte count in the absence of seizures. Methods. We performed a retrospective chart review of adult epilepsy patients presenting for evaluation over a four-month period. Demographics, epilepsy type and characteristics, number and type of antiepileptic drugs, as well as medical co-morbidities were noted. Results. A total of 241 patients fulfilled study criteria. Variables correlating with leukocyte count were identified using univariate analysis. Based on multivariate analysis, only the correlation with type of epilepsy and use of more than two antiepileptic drugs remained statistically significant. Patients with generalised epilepsy had a higher leukocyte count (7.21 k/μL) compared to those with focal epilepsy (6.53 k/μL); the main difference was due to the number of monocytes. Conclusion. These findings raise the possibility that there are different neuro-immune profiles between patients with generalised and focal epilepsy.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalEpileptic Disorders
Volume14
Issue number1
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Immune
  • Leukocyte
  • Monocyte

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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