Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative

Margery L S Gass, Barbara B. Cochrane, Joseph C. Larson, Joann E. Manson, Vanessa M. Barnabei, Robert G. Brzyski, Dorothy S. Lane, June Lavalleur, Judith K. Ockene, Charles Mouton, David H. Barad

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to determine the patterns and predictors of sexual activity in the Hormone Therapy (HT) Trials of the Women's Health Initiative (WHI). Methods: Sexual activity questions were administered to 27,347 women ages 50 to 79 years at baseline and at year 1 and to a random 8.6% subsample at years 3 and 6. The associations with demographic and health characteristics were determined. Results: Sexual activity at baseline was 60.7%, 44.9%, and 28.2% in the 50-to 59-, 60-to 69-, and 70-to 79-year-old age groups, respectively. Most of the participants were satisfied with their current sexual activity (63.2%). Of those dissatisfied, 57% preferred more sexual activity. Vaginal atrophy correlated with sexual inactivity at baseline (P < 0.001). The correlates associated with stopping sexual activity at year 1 included poor/fair self-rated health, lack of satisfaction with quality of life, depression, and loss of partner (P < 0.001). The strongest predictor of sexual activity at year 1 was sexual activity at baseline (odds ratio, 96.71; 95% CI, 81.90-114.20). A subset analysis of women adherent with HT or placebo at years 3 and 6 suggested that HT was associated with a higher percentage of participants reporting sexual activity (P = 0.01). Conclusions: Most women in the WHI HT Trials were satisfied with their sexual activity. Of those who were dissatisfied, the majority preferred more, rather than less, sexual activity. Vaginal atrophy at baseline correlated with sexual inactivity, and sexual activity at baseline was the strongest identified predictor of sexual activity at year 1. HT use was not predictive of ongoing sexual activity in the intent-to-treat analysis. This report further characterizes the participants in the WHI HT trials and reveals the complexity of factors related to the prevalence of sexual activity and satisfaction.

Original languageEnglish (US)
Pages (from-to)1160-1171
Number of pages12
JournalMenopause
Volume18
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Fingerprint

Women's Health
Sexual Behavior
Hormones
Therapeutics
Atrophy
Orgasm
Health

Keywords

  • Hormone therapy
  • Postmenopausal women
  • Predictors
  • Sexual activity
  • Sexual satisfaction
  • Women's Health Initiative

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Gass, M. L. S., Cochrane, B. B., Larson, J. C., Manson, J. E., Barnabei, V. M., Brzyski, R. G., ... Barad, D. H. (2011). Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative. Menopause, 18(11), 1160-1171. https://doi.org/10.1097/gme.0b013e3182227ebd

Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative. / Gass, Margery L S; Cochrane, Barbara B.; Larson, Joseph C.; Manson, Joann E.; Barnabei, Vanessa M.; Brzyski, Robert G.; Lane, Dorothy S.; Lavalleur, June; Ockene, Judith K.; Mouton, Charles; Barad, David H.

In: Menopause, Vol. 18, No. 11, 11.2011, p. 1160-1171.

Research output: Contribution to journalArticle

Gass, MLS, Cochrane, BB, Larson, JC, Manson, JE, Barnabei, VM, Brzyski, RG, Lane, DS, Lavalleur, J, Ockene, JK, Mouton, C & Barad, DH 2011, 'Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative', Menopause, vol. 18, no. 11, pp. 1160-1171. https://doi.org/10.1097/gme.0b013e3182227ebd
Gass, Margery L S ; Cochrane, Barbara B. ; Larson, Joseph C. ; Manson, Joann E. ; Barnabei, Vanessa M. ; Brzyski, Robert G. ; Lane, Dorothy S. ; Lavalleur, June ; Ockene, Judith K. ; Mouton, Charles ; Barad, David H. / Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's Health Initiative. In: Menopause. 2011 ; Vol. 18, No. 11. pp. 1160-1171.
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abstract = "Objective: The aim of this study was to determine the patterns and predictors of sexual activity in the Hormone Therapy (HT) Trials of the Women's Health Initiative (WHI). Methods: Sexual activity questions were administered to 27,347 women ages 50 to 79 years at baseline and at year 1 and to a random 8.6{\%} subsample at years 3 and 6. The associations with demographic and health characteristics were determined. Results: Sexual activity at baseline was 60.7{\%}, 44.9{\%}, and 28.2{\%} in the 50-to 59-, 60-to 69-, and 70-to 79-year-old age groups, respectively. Most of the participants were satisfied with their current sexual activity (63.2{\%}). Of those dissatisfied, 57{\%} preferred more sexual activity. Vaginal atrophy correlated with sexual inactivity at baseline (P < 0.001). The correlates associated with stopping sexual activity at year 1 included poor/fair self-rated health, lack of satisfaction with quality of life, depression, and loss of partner (P < 0.001). The strongest predictor of sexual activity at year 1 was sexual activity at baseline (odds ratio, 96.71; 95{\%} CI, 81.90-114.20). A subset analysis of women adherent with HT or placebo at years 3 and 6 suggested that HT was associated with a higher percentage of participants reporting sexual activity (P = 0.01). Conclusions: Most women in the WHI HT Trials were satisfied with their sexual activity. Of those who were dissatisfied, the majority preferred more, rather than less, sexual activity. Vaginal atrophy at baseline correlated with sexual inactivity, and sexual activity at baseline was the strongest identified predictor of sexual activity at year 1. HT use was not predictive of ongoing sexual activity in the intent-to-treat analysis. This report further characterizes the participants in the WHI HT trials and reveals the complexity of factors related to the prevalence of sexual activity and satisfaction.",
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AU - Barnabei, Vanessa M.

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