Patterns of association with host and habitat: Antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States

James N. Mills, Thomas G. Ksiazek, Barbara A. Ellis, Pierre E. Rollin, Stuart T. Nichol, Terry L. Yates, William L. Gannon, Craig E. Levy, David M. Engelthaler, Ted Davis, Dale T. Tanda, J. Wyatt Frampton, Craig R. Nichols, C. J. Peters, James E. Childs

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

The distribution and prevalence of antibody reactive with Sin Nombre virus were determined in mammals in biotic communities of the southwestern United States. Small mammals (n = 3,069) of 69 species were trapped in nine communities from lower Sonoran desert to alpine tundra. Antibody was found in rodents from all communities (overall prevalence = 6.3%); prevalence was lowest at the altitudinal and climatic extremes (0.4% in desert and 2.0% in alpine tundra). Antibody occurred in 11% of 928 deer mice, 20% of 355 brush mice, 23% of 35 western harvest mice, and 12% of 24 Mexican voles. No infected deer mice were found in desert habitat; prevalence varied from 4% in chaparral to 17% in pinyon-juniper. Brush mice were frequently infected in chaparral and montane forest (25%). Seropositivity was higher in males and in heavier animals, suggesting horizontal transmission among adult males. Decreasing prevalence with age among the youngest deer mice suggests that infected dams confer passive immunity to pups.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume56
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Mills, J. N., Ksiazek, T. G., Ellis, B. A., Rollin, P. E., Nichol, S. T., Yates, T. L., Gannon, W. L., Levy, C. E., Engelthaler, D. M., Davis, T., Tanda, D. T., Frampton, J. W., Nichols, C. R., Peters, C. J., & Childs, J. E. (1997). Patterns of association with host and habitat: Antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. American Journal of Tropical Medicine and Hygiene, 56(3), 273-284. https://doi.org/10.4269/ajtmh.1997.56.273