Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries

A multicenter study

Frederick J. Stoddard, Gwyne W. White, Lewis E. Kazis, J. Michael Murphy, Erica A. Sorrentino, Michelle Hinson, Teresa Kim Stubbs, Grace Chan, Robert L. Sheridan, Tina Palmieri, Richard Kagan, David Herndon, Ronald G. Tompkins

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Children with burn injuries receive a broad range of medications, from analgesics to antipsychotics, but how utilization of these drugs differs from one pediatric burn center to another is unclear. This study examined utilization patterns of six categories of medication administered acutely to burned children as a first step in creating evidence-based practice guidelines. Six medications administered to pediatric patients enrolled in a multicenter study were recorded from patient charts using a standardized chart review template. The medication categories included opiates, benzodiazepines, antidepressants, beta-blockers, two different anesthetics, and antipsychotics. Data were analyzed by χ and logistical regression analysis. Analysis of data from three sites and 470 patients revealed significant differences in prescription patterns across hospitals for all medication groups except opiates. Differences were significant for benzodiazepines and antidepressants (χ = 7.3; P < .01 for both) controlling for age, gender, race, language, burn size, and length of stay. Differences in prescribing patterns for beta-blockers and the anesthetics ketamine and propofol failed to reach statistical significance; however, the results did trend in that direction (χ = 3.8 and 3.4, respectively; P < .10 for both). The pharmacotherapeutic agents described in this study are an integral part of acute pediatric burn care, and yet there is variation in use of these medications among the centers. The differences in prescribing indicate that, for certain drugs, a range of approaches to pharmacotherapeutics is being used and suggest that evidence-based guidelines for administration of these agents need to be developed.

Original languageEnglish (US)
Pages (from-to)519-528
Number of pages10
JournalJournal of Burn Care and Research
Volume32
Issue number5
DOIs
StatePublished - Sep 2011

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Opiate Alkaloids
Multicenter Studies
Pediatrics
Benzodiazepines
Antidepressive Agents
Antipsychotic Agents
Anesthetics
Wounds and Injuries
Burn Units
Evidence-Based Practice
Ketamine
Propofol
Practice Guidelines
Prescriptions
Analgesics
Length of Stay
Language
Therapeutics
Regression Analysis
Guidelines

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Stoddard, F. J., White, G. W., Kazis, L. E., Murphy, J. M., Sorrentino, E. A., Hinson, M., ... Tompkins, R. G. (2011). Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: A multicenter study. Journal of Burn Care and Research, 32(5), 519-528. https://doi.org/10.1097/BCR.0b013e31822bef92

Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries : A multicenter study. / Stoddard, Frederick J.; White, Gwyne W.; Kazis, Lewis E.; Murphy, J. Michael; Sorrentino, Erica A.; Hinson, Michelle; Kim Stubbs, Teresa; Chan, Grace; Sheridan, Robert L.; Palmieri, Tina; Kagan, Richard; Herndon, David; Tompkins, Ronald G.

In: Journal of Burn Care and Research, Vol. 32, No. 5, 09.2011, p. 519-528.

Research output: Contribution to journalArticle

Stoddard, FJ, White, GW, Kazis, LE, Murphy, JM, Sorrentino, EA, Hinson, M, Kim Stubbs, T, Chan, G, Sheridan, RL, Palmieri, T, Kagan, R, Herndon, D & Tompkins, RG 2011, 'Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: A multicenter study', Journal of Burn Care and Research, vol. 32, no. 5, pp. 519-528. https://doi.org/10.1097/BCR.0b013e31822bef92
Stoddard, Frederick J. ; White, Gwyne W. ; Kazis, Lewis E. ; Murphy, J. Michael ; Sorrentino, Erica A. ; Hinson, Michelle ; Kim Stubbs, Teresa ; Chan, Grace ; Sheridan, Robert L. ; Palmieri, Tina ; Kagan, Richard ; Herndon, David ; Tompkins, Ronald G. / Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries : A multicenter study. In: Journal of Burn Care and Research. 2011 ; Vol. 32, No. 5. pp. 519-528.
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