Pediatric en bloc kidney transplantation to adult recipients: More than suboptimal?

Suverta Bhayana, Yong Fang Kuo, Pankaj Madan, Sreedhar Mandaym, Philip G. Thomas, Jacqueline A. Lappin, James C. Rice, Kanae Ishihara

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: To optimize available organs, kidneys from young donors traditionally beleived to be suboptimal are transplanted to adults. The purpose of this study is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other deceased donor transplants in adult recipients. Methods: We analyzed United Network of Organ Sharing/STAR data on primary deceased donor kidney transplants to adult recipients (1988-2006). EBK (age younger than 5 years, n=1696) was compared with solitary pediatric (SP; age younger than 5 years) kidneys (n=1502), and matched standard adult donors (age 18-59 years, n=9594) and expanded criteria donor (ECD; n=6396). The adjusted GS was obtained using Cox proportional hazard model and hazard ratios were calculated. Results: EBK had lowest acute rejection rates (6.0%) but similar to standard adult transplants (6.3%), and lower than SP and ECD (9.0% and 8.2%; P<0.0001). Delayed graft function rates were lowest in EBK (17.9%), highest in ECD (34.8%; P<0.0001), and similar among SP and standard adult transplants (24.4% and 24.2%). The estimated glomerular filtration rate (eGFR) was best in EBK and worst in ECD (P<0.0001). The eGFR of EBK and SP transplants continuously improved but the eGFR of standard adult and ECD declined. Graft loss was higher in EBK and SP transplants than adult donor transplants during the first 6 months. Despite the highest thrombosis rates in EBK (5.0%) (SP, 3.3%; standard adult, 1.8%; ECD, 2.0%, P<0.0001), GS of EBK became similar to standard adult donor transplants by 5 years and best at 10 years posttransplant (64.0%) and worst in ECD (39.6%; P<0.0001). Conclusion: EBK had the best long-term outcomes among deceased donor transplants and offer unique options for adult kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalTransplantation
Volume90
Issue number3
DOIs
StatePublished - Aug 15 2010

Fingerprint

Kidney Transplantation
Pediatrics
Kidney
Tissue Donors
Transplants
Graft Survival
Glomerular Filtration Rate
Delayed Graft Function
Information Dissemination
Proportional Hazards Models
Thrombosis

Keywords

  • Deceased donor
  • En bloc
  • GFR
  • Graft survival
  • Kidney transplantation
  • Pediatric donor
  • UNOS

ASJC Scopus subject areas

  • Transplantation

Cite this

Bhayana, S., Kuo, Y. F., Madan, P., Mandaym, S., Thomas, P. G., Lappin, J. A., ... Ishihara, K. (2010). Pediatric en bloc kidney transplantation to adult recipients: More than suboptimal? Transplantation, 90(3), 248-254. https://doi.org/10.1097/TP.0b013e3181e641f8

Pediatric en bloc kidney transplantation to adult recipients : More than suboptimal? / Bhayana, Suverta; Kuo, Yong Fang; Madan, Pankaj; Mandaym, Sreedhar; Thomas, Philip G.; Lappin, Jacqueline A.; Rice, James C.; Ishihara, Kanae.

In: Transplantation, Vol. 90, No. 3, 15.08.2010, p. 248-254.

Research output: Contribution to journalArticle

Bhayana, S, Kuo, YF, Madan, P, Mandaym, S, Thomas, PG, Lappin, JA, Rice, JC & Ishihara, K 2010, 'Pediatric en bloc kidney transplantation to adult recipients: More than suboptimal?', Transplantation, vol. 90, no. 3, pp. 248-254. https://doi.org/10.1097/TP.0b013e3181e641f8
Bhayana, Suverta ; Kuo, Yong Fang ; Madan, Pankaj ; Mandaym, Sreedhar ; Thomas, Philip G. ; Lappin, Jacqueline A. ; Rice, James C. ; Ishihara, Kanae. / Pediatric en bloc kidney transplantation to adult recipients : More than suboptimal?. In: Transplantation. 2010 ; Vol. 90, No. 3. pp. 248-254.
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abstract = "Background: To optimize available organs, kidneys from young donors traditionally beleived to be suboptimal are transplanted to adults. The purpose of this study is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other deceased donor transplants in adult recipients. Methods: We analyzed United Network of Organ Sharing/STAR data on primary deceased donor kidney transplants to adult recipients (1988-2006). EBK (age younger than 5 years, n=1696) was compared with solitary pediatric (SP; age younger than 5 years) kidneys (n=1502), and matched standard adult donors (age 18-59 years, n=9594) and expanded criteria donor (ECD; n=6396). The adjusted GS was obtained using Cox proportional hazard model and hazard ratios were calculated. Results: EBK had lowest acute rejection rates (6.0{\%}) but similar to standard adult transplants (6.3{\%}), and lower than SP and ECD (9.0{\%} and 8.2{\%}; P<0.0001). Delayed graft function rates were lowest in EBK (17.9{\%}), highest in ECD (34.8{\%}; P<0.0001), and similar among SP and standard adult transplants (24.4{\%} and 24.2{\%}). The estimated glomerular filtration rate (eGFR) was best in EBK and worst in ECD (P<0.0001). The eGFR of EBK and SP transplants continuously improved but the eGFR of standard adult and ECD declined. Graft loss was higher in EBK and SP transplants than adult donor transplants during the first 6 months. Despite the highest thrombosis rates in EBK (5.0{\%}) (SP, 3.3{\%}; standard adult, 1.8{\%}; ECD, 2.0{\%}, P<0.0001), GS of EBK became similar to standard adult donor transplants by 5 years and best at 10 years posttransplant (64.0{\%}) and worst in ECD (39.6{\%}; P<0.0001). Conclusion: EBK had the best long-term outcomes among deceased donor transplants and offer unique options for adult kidney transplant recipients.",
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AU - Thomas, Philip G.

AU - Lappin, Jacqueline A.

AU - Rice, James C.

AU - Ishihara, Kanae

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N2 - Background: To optimize available organs, kidneys from young donors traditionally beleived to be suboptimal are transplanted to adults. The purpose of this study is to compare graft survival (GS) of en bloc kidney (EBK) from young pediatric donors to other deceased donor transplants in adult recipients. Methods: We analyzed United Network of Organ Sharing/STAR data on primary deceased donor kidney transplants to adult recipients (1988-2006). EBK (age younger than 5 years, n=1696) was compared with solitary pediatric (SP; age younger than 5 years) kidneys (n=1502), and matched standard adult donors (age 18-59 years, n=9594) and expanded criteria donor (ECD; n=6396). The adjusted GS was obtained using Cox proportional hazard model and hazard ratios were calculated. Results: EBK had lowest acute rejection rates (6.0%) but similar to standard adult transplants (6.3%), and lower than SP and ECD (9.0% and 8.2%; P<0.0001). Delayed graft function rates were lowest in EBK (17.9%), highest in ECD (34.8%; P<0.0001), and similar among SP and standard adult transplants (24.4% and 24.2%). The estimated glomerular filtration rate (eGFR) was best in EBK and worst in ECD (P<0.0001). The eGFR of EBK and SP transplants continuously improved but the eGFR of standard adult and ECD declined. Graft loss was higher in EBK and SP transplants than adult donor transplants during the first 6 months. Despite the highest thrombosis rates in EBK (5.0%) (SP, 3.3%; standard adult, 1.8%; ECD, 2.0%, P<0.0001), GS of EBK became similar to standard adult donor transplants by 5 years and best at 10 years posttransplant (64.0%) and worst in ECD (39.6%; P<0.0001). Conclusion: EBK had the best long-term outcomes among deceased donor transplants and offer unique options for adult kidney transplant recipients.

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