Pediatric intracranial arteriovenous malformations: A single-center experience

Melissa A. LoPresti, Vijay M. Ravindra, Monika Pyarali, Eric Goethe, Nisha Gadgil, Kathyrn Wagner, Peter Kan, Sandi Lam

Research output: Contribution to journalArticle

Abstract

OBJECTIVE Intracranial arteriovenous malformations (AVMs) are a common cause of intracranial hemorrhage in children. Exploring outcomes of treatment and factors that predict recurrence may help guide the management of pediatric AVMs. In this study, the authors review a single-center experience with pediatric AVMs, aiming to identify factors contributing to recurrence and areas for improvement in treatment. METHODS A single-center retrospective review of patients ages 0–18 years with AVMs in the period from 2005 to 2018 was conducted. Demographic, clinical, and radiographic data were collected and examined to compare the clinical and functional outcomes of patients managed with and those managed without open microsurgical resection. RESULTS One hundred five patients were diagnosed and treated during the study period. Fifty (47.6%) had been treated surgically and 35 (33.3%) nonsurgically, and 20 (19%) had been treated primarily at an outside institution and thus were excluded from further analysis. Of the 50 treated surgically, 92% had complete obliteration on postoperative imaging, with the remaining patients having residual AVM and undergoing re-resection or SRS, ultimately resulting in a 96% radiographic cure rate. The surgically treated patients were followed up for an average of 3.34 years. Eighty-two percent had a modified Rankin Scale (mRS) score of 0–2. There was a recurrence rate of 12%, with the time to recurrence averaging 327.86 days (range 85–596 days). Of the 35 patients managed without open surgery, 77% underwent serial imaging surveillance, 20% underwent endovascular embolization, and 3% underwent stereotactic radiosurgery. Radiographic cure was seen in 6% of those treated nonsurgically, and all had undergone endovascular treatment alone. The nonsurgically treated patients were followed up for an average of 2.14 years. Eighty percent had an mRS score of 0–2. CONCLUSIONS The data revealed that patients with lower-grade AVMs treated surgically and those with higher-grade AVMs managed without surgery have good functional and clinical outcomes. A high rate of recurrence was noted, and the possible contributing factors were explored. The authors encourage further study into mechanisms to reduce AVM recurrence in pediatric patients and look forward to advances in the medical management of lesions that are considered unresectable.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalJournal of Neurosurgery: Pediatrics
Volume25
Issue number2
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Cerebral arteriovenous malformations
  • Outcomes
  • Pediatrics
  • Recurrence
  • Vascular disorders

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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    LoPresti, M. A., Ravindra, V. M., Pyarali, M., Goethe, E., Gadgil, N., Wagner, K., Kan, P., & Lam, S. (2020). Pediatric intracranial arteriovenous malformations: A single-center experience. Journal of Neurosurgery: Pediatrics, 25(2), 151-158. https://doi.org/10.3171/2019.9.PEDS19235