Abstract
Introduction: Novel approaches are urgently needed to achieve the next level of control of HIV infection beyond antiretroviral medications that will lead to the ultimate goal of curing HIV infection. Exploiting the innate immune system control of HIV is one possible component of that strategy with pegylated interferon representing a well-characterized agent that is being applied to this effort.Areas covered: In this review, the authors summarize the history of interferon treatment in the setting of HIV infection with a focus on clinical trials that examined the downstream effects on innate immune responses. More recently, clinical trials that administered pegylated interferon 2a have demonstrated which interferon-stimulated genes are associated with its antiviral effects and which of these host-restriction factors may play a role in limiting the magnitude of the HIV reservoir.Expert opinion: The potential to exploit interferon as part of a cure strategy is provocative. Whether key interferon-induced antiviral factors can be upregulated sufficiently to affect the reservoir is unknown. Additional research employing pegylated interferon 2a is needed to identify which innate immune pathways are candidate targets for novel biological therapies for the potential cure of HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-257 |
| Number of pages | 9 |
| Journal | Expert Opinion on Investigational Drugs |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- HIV
- HIV reservoir
- humans
- innate immune system
- Interferon alpha
- interferon stimulated genes
- review
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Peginterferon 2a for the treatment of HIV infection. / Asmuth, David M.; Utay, Netanya S.; Pollard, Richard B.
In: Expert Opinion on Investigational Drugs, Vol. 25, No. 2, 01.02.2016, p. 249-257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peginterferon 2a for the treatment of HIV infection
AU - Asmuth, David M.
AU - Utay, Netanya S.
AU - Pollard, Richard B.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Introduction: Novel approaches are urgently needed to achieve the next level of control of HIV infection beyond antiretroviral medications that will lead to the ultimate goal of curing HIV infection. Exploiting the innate immune system control of HIV is one possible component of that strategy with pegylated interferon representing a well-characterized agent that is being applied to this effort.Areas covered: In this review, the authors summarize the history of interferon treatment in the setting of HIV infection with a focus on clinical trials that examined the downstream effects on innate immune responses. More recently, clinical trials that administered pegylated interferon 2a have demonstrated which interferon-stimulated genes are associated with its antiviral effects and which of these host-restriction factors may play a role in limiting the magnitude of the HIV reservoir.Expert opinion: The potential to exploit interferon as part of a cure strategy is provocative. Whether key interferon-induced antiviral factors can be upregulated sufficiently to affect the reservoir is unknown. Additional research employing pegylated interferon 2a is needed to identify which innate immune pathways are candidate targets for novel biological therapies for the potential cure of HIV infection.
AB - Introduction: Novel approaches are urgently needed to achieve the next level of control of HIV infection beyond antiretroviral medications that will lead to the ultimate goal of curing HIV infection. Exploiting the innate immune system control of HIV is one possible component of that strategy with pegylated interferon representing a well-characterized agent that is being applied to this effort.Areas covered: In this review, the authors summarize the history of interferon treatment in the setting of HIV infection with a focus on clinical trials that examined the downstream effects on innate immune responses. More recently, clinical trials that administered pegylated interferon 2a have demonstrated which interferon-stimulated genes are associated with its antiviral effects and which of these host-restriction factors may play a role in limiting the magnitude of the HIV reservoir.Expert opinion: The potential to exploit interferon as part of a cure strategy is provocative. Whether key interferon-induced antiviral factors can be upregulated sufficiently to affect the reservoir is unknown. Additional research employing pegylated interferon 2a is needed to identify which innate immune pathways are candidate targets for novel biological therapies for the potential cure of HIV infection.
KW - HIV
KW - HIV reservoir
KW - humans
KW - innate immune system
KW - Interferon alpha
KW - interferon stimulated genes
KW - review
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U2 - 10.1517/13543784.2016.1132699
DO - 10.1517/13543784.2016.1132699
M3 - Article
VL - 25
SP - 249
EP - 257
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
SN - 1354-3784
IS - 2
ER -