Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease

David L. Bowton, David A. Stump, Donald S. Prough, James F. Toole, David S. Lefkowitz, Laura Coker

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease;four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the xenon-133 clearance technique with 16 detectors (eight per hemisphere). Global cerebral blood flow as a percentage of the baseline value increased significantly after 800 mg but not 400 mg pentoxifylline (p=0.017 and p=0.29, respectively). Regional cerebral blood flow as a percentage of the baseline value at the detector with the lowest baseline value increased significantly 2 hours after both 400 mg and 800 mg pentoxifylline (p=0.038 and p=0.010, respectively). Cerebrovascular reactivity to carbon dioxide was preserved despite the increases in cerebral blood flow. Pentoxifylline increases cerebral blood flow and is not associated with “intracerebral steal” in patients with cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)1662-1666
Number of pages5
JournalStroke
Volume20
Issue number12
DOIs
StatePublished - Dec 1989
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Bowton, D. L., Stump, D. A., Prough, D. S., Toole, J. F., Lefkowitz, D. S., & Coker, L. (1989). Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. Stroke, 20(12), 1662-1666. https://doi.org/10.1161/01.STR.20.12.1662