Peptide YY

Guillermo Gomez, T. Zhang, F. Lluis, Courtney Townsend, J. C. Thompson, G. H. Greeley

Research output: Contribution to journalArticle

Abstract

Peptide YY (PYY) is a gut regulatory peptide localized primarily in endocrine cells lining the lumen of the distal small bowel and colon. Pharmacologic studies have shown that IV administration of PYY can inhibit stimulated levels of gastric acid and pancreatic exocrine secretion as well as gastric emptying and intestinal transit. Oral ingestion and intraduodenal infusion of fat results in a prompt elevation in circulating levels from lower gut stores of PYY, suggesting that release of PYY is controlled by neural and endocrine pathways. More recently, we have found that suppression of acid secretion by various agents (omeprazole, famotidine, secretin) inhibits food-induced release of PYY. Secretion of PYY is reestablished, in part, by administration of an acidified meal in omeprazole-treated dogs. Corresponding studies of the rat colon show that suppression of gastric acid secretion results in a decrease in PYY gene expression and PYY peptide levels which is due, in part, to gastrin. Together, these findings suggest that gastric acid secretion participates in the physiologic release of PYY and that the effects of gastric acid are mediated partly by gastrin.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalBiomedical Research
Volume16
Issue numberSUPPL. 2
StatePublished - 1995

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Peptide YY
Gastric Acid
Acids
Omeprazole
Gastrins
Colon
Famotidine
Neural Pathways
Peptides
Secretin
Endocrine Cells
Gastric Emptying
Linings
Gene expression
Meals
Rats
Eating
Fats
Cells
Dogs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gomez, G., Zhang, T., Lluis, F., Townsend, C., Thompson, J. C., & Greeley, G. H. (1995). Peptide YY. Biomedical Research, 16(SUPPL. 2), 147-150.

Peptide YY. / Gomez, Guillermo; Zhang, T.; Lluis, F.; Townsend, Courtney; Thompson, J. C.; Greeley, G. H.

In: Biomedical Research, Vol. 16, No. SUPPL. 2, 1995, p. 147-150.

Research output: Contribution to journalArticle

Gomez, G, Zhang, T, Lluis, F, Townsend, C, Thompson, JC & Greeley, GH 1995, 'Peptide YY', Biomedical Research, vol. 16, no. SUPPL. 2, pp. 147-150.
Gomez G, Zhang T, Lluis F, Townsend C, Thompson JC, Greeley GH. Peptide YY. Biomedical Research. 1995;16(SUPPL. 2):147-150.
Gomez, Guillermo ; Zhang, T. ; Lluis, F. ; Townsend, Courtney ; Thompson, J. C. ; Greeley, G. H. / Peptide YY. In: Biomedical Research. 1995 ; Vol. 16, No. SUPPL. 2. pp. 147-150.
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