Peptide YY

Guillermo Gomez, Guiyun Wang, Ella Englander, George H. Greeley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on peptide YY (PYY), a 36-amino-acid peptide hormone that is structurally similar to two other gut peptides, pancreatic polypeptide (PP), and neuropeptide Y (NPY). PYY is produced primarily in enteroendocrine L cells in the intestinal epithelium of the ileum-colon and is a candidate enterogastrone because PYY is secreted into the systemic circulation in response to dietary fat and is a potent inhibitor of gastric acid secretion. Much lower amounts of PYY are produced in the stomach antrum, proximal small intestine, and pancreatic endocrine cells. In the distal intestine PYY is co-produced with proglucagon, and in the pancreas PYY may reside with glucagon or PPPYY can also inhibit pancreatic exocrine secretion, gastric emptying intestinal transit, and intestinal fluid secretion. Because of its potent antisecretory action, PYY may be an endogenous inhibitor of diarrhea. PYY enhance intestinal absorption of fluid and electrolytes in the jejunum and ileum. In fact, the administration of PYY or PYY analogs into the intestinal lumen is proabsorptive. In support of the antisecretory action of PYY, PYY receptors can be localized in the intestinal crypt cells where chloride secretion occurs.

Original languageEnglish (US)
Title of host publicationHandbook of Biologically Active Peptides
PublisherElsevier Inc.
Pages1109-1114
Number of pages6
ISBN (Print)9780123694423
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Peptide YY
Ileum
Proglucagon
Enteroendocrine Cells
Intestinal Secretions
Fluids and Secretions
Pancreatic Polypeptide
Endocrine Cells
Fluids
Peptide Hormones
Gastric Emptying
Dietary Fats
Neuropeptide Y
Gastric Acid
Intestinal Absorption
Jejunum
Intestinal Mucosa
Glucagon
Electrolytes
Small Intestine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gomez, G., Wang, G., Englander, E., & Greeley, G. H. (2006). Peptide YY. In Handbook of Biologically Active Peptides (pp. 1109-1114). Elsevier Inc.. https://doi.org/10.1016/B978-012369442-3/50155-0

Peptide YY. / Gomez, Guillermo; Wang, Guiyun; Englander, Ella; Greeley, George H.

Handbook of Biologically Active Peptides. Elsevier Inc., 2006. p. 1109-1114.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gomez, G, Wang, G, Englander, E & Greeley, GH 2006, Peptide YY. in Handbook of Biologically Active Peptides. Elsevier Inc., pp. 1109-1114. https://doi.org/10.1016/B978-012369442-3/50155-0
Gomez G, Wang G, Englander E, Greeley GH. Peptide YY. In Handbook of Biologically Active Peptides. Elsevier Inc. 2006. p. 1109-1114 https://doi.org/10.1016/B978-012369442-3/50155-0
Gomez, Guillermo ; Wang, Guiyun ; Englander, Ella ; Greeley, George H. / Peptide YY. Handbook of Biologically Active Peptides. Elsevier Inc., 2006. pp. 1109-1114
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