Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system.

P. Clave, F. Lluis, J. C. Thompson, G. H. Greeley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peptide YY (PYY), a new peptide found primarily in mucosal endocrine cells of the terminal ileum and colon, inhibits pentagastrin-stimulated gastric acid secretion in several species, including man. Several studies indicate that PYY can affect autonomic neurotransmission, and we have recently shown that PYY can inhibit neurally stimulated release of insulin. The purpose of the present study was to examine the effect of PYY on gastric acid secretion stimulated by the autonomic nervous system. On separate days, 6 dogs that were prepared with chronic gastric cannulas were given 2-deoxy-D-glucose (2-DG; 90 mg/kg, i.v.) for 6 min, either alone, or in combination with PYY (100, 200, or 400 pmol.kg-1.h-1, i.v.) for 60 min. The effect of PYY, at 400 pmol.kg-1.h-1, on gastric acid secretion stimulated by either 2-DG or PG (1 micrograms.kg-1.h-1, i.v.) was studied after treatment with propranolol (0.5 mg/kg, i.v. bolus) or phentolamine 1 mg/kg, i.v. bolus). PYY reduced the 2-DG-stimulated secretion of gastric acid in a dose-dependent manner. PYY, given at 100 pmol.kg-1.h-1, reduced gastric acid output by 29 +/- 17%; PYY, at 200, by 41 +/- 7% (p < 0.05), and PYY, at 400, by 52 +/- 8% (p < 0.05). The inhibitory action of PYY on 2-DG-stimulated secretion of gastric acid persisted after treatment with phentolamine (69 +/- 14%; p < 0.05), but it was blocked by treatment with propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalBiological Signals
Volume1
Issue number1
StatePublished - Jan 1992

Fingerprint

Peptide YY
Gastric Acid
Autonomic Nervous System
Neurology
Acids
Phentolamine
Propranolol
Pentagastrin
Endocrine Cells
Deoxyglucose
Ileum
Synaptic Transmission
Stomach
Colon

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Clave, P., Lluis, F., Thompson, J. C., & Greeley, G. H. (1992). Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system. Biological Signals, 1(1), 40-45.

Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system. / Clave, P.; Lluis, F.; Thompson, J. C.; Greeley, G. H.

In: Biological Signals, Vol. 1, No. 1, 01.1992, p. 40-45.

Research output: Contribution to journalArticle

Clave, P, Lluis, F, Thompson, JC & Greeley, GH 1992, 'Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system.', Biological Signals, vol. 1, no. 1, pp. 40-45.
Clave, P. ; Lluis, F. ; Thompson, J. C. ; Greeley, G. H. / Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system. In: Biological Signals. 1992 ; Vol. 1, No. 1. pp. 40-45.
@article{7d0eb4638c9346459ca6d0455be2bfb0,
title = "Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system.",
abstract = "Peptide YY (PYY), a new peptide found primarily in mucosal endocrine cells of the terminal ileum and colon, inhibits pentagastrin-stimulated gastric acid secretion in several species, including man. Several studies indicate that PYY can affect autonomic neurotransmission, and we have recently shown that PYY can inhibit neurally stimulated release of insulin. The purpose of the present study was to examine the effect of PYY on gastric acid secretion stimulated by the autonomic nervous system. On separate days, 6 dogs that were prepared with chronic gastric cannulas were given 2-deoxy-D-glucose (2-DG; 90 mg/kg, i.v.) for 6 min, either alone, or in combination with PYY (100, 200, or 400 pmol.kg-1.h-1, i.v.) for 60 min. The effect of PYY, at 400 pmol.kg-1.h-1, on gastric acid secretion stimulated by either 2-DG or PG (1 micrograms.kg-1.h-1, i.v.) was studied after treatment with propranolol (0.5 mg/kg, i.v. bolus) or phentolamine 1 mg/kg, i.v. bolus). PYY reduced the 2-DG-stimulated secretion of gastric acid in a dose-dependent manner. PYY, given at 100 pmol.kg-1.h-1, reduced gastric acid output by 29 +/- 17{\%}; PYY, at 200, by 41 +/- 7{\%} (p < 0.05), and PYY, at 400, by 52 +/- 8{\%} (p < 0.05). The inhibitory action of PYY on 2-DG-stimulated secretion of gastric acid persisted after treatment with phentolamine (69 +/- 14{\%}; p < 0.05), but it was blocked by treatment with propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "P. Clave and F. Lluis and Thompson, {J. C.} and Greeley, {G. H.}",
year = "1992",
month = "1",
language = "English (US)",
volume = "1",
pages = "40--45",
journal = "Neuro-Signals",
issn = "1424-862X",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system.

AU - Clave, P.

AU - Lluis, F.

AU - Thompson, J. C.

AU - Greeley, G. H.

PY - 1992/1

Y1 - 1992/1

N2 - Peptide YY (PYY), a new peptide found primarily in mucosal endocrine cells of the terminal ileum and colon, inhibits pentagastrin-stimulated gastric acid secretion in several species, including man. Several studies indicate that PYY can affect autonomic neurotransmission, and we have recently shown that PYY can inhibit neurally stimulated release of insulin. The purpose of the present study was to examine the effect of PYY on gastric acid secretion stimulated by the autonomic nervous system. On separate days, 6 dogs that were prepared with chronic gastric cannulas were given 2-deoxy-D-glucose (2-DG; 90 mg/kg, i.v.) for 6 min, either alone, or in combination with PYY (100, 200, or 400 pmol.kg-1.h-1, i.v.) for 60 min. The effect of PYY, at 400 pmol.kg-1.h-1, on gastric acid secretion stimulated by either 2-DG or PG (1 micrograms.kg-1.h-1, i.v.) was studied after treatment with propranolol (0.5 mg/kg, i.v. bolus) or phentolamine 1 mg/kg, i.v. bolus). PYY reduced the 2-DG-stimulated secretion of gastric acid in a dose-dependent manner. PYY, given at 100 pmol.kg-1.h-1, reduced gastric acid output by 29 +/- 17%; PYY, at 200, by 41 +/- 7% (p < 0.05), and PYY, at 400, by 52 +/- 8% (p < 0.05). The inhibitory action of PYY on 2-DG-stimulated secretion of gastric acid persisted after treatment with phentolamine (69 +/- 14%; p < 0.05), but it was blocked by treatment with propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Peptide YY (PYY), a new peptide found primarily in mucosal endocrine cells of the terminal ileum and colon, inhibits pentagastrin-stimulated gastric acid secretion in several species, including man. Several studies indicate that PYY can affect autonomic neurotransmission, and we have recently shown that PYY can inhibit neurally stimulated release of insulin. The purpose of the present study was to examine the effect of PYY on gastric acid secretion stimulated by the autonomic nervous system. On separate days, 6 dogs that were prepared with chronic gastric cannulas were given 2-deoxy-D-glucose (2-DG; 90 mg/kg, i.v.) for 6 min, either alone, or in combination with PYY (100, 200, or 400 pmol.kg-1.h-1, i.v.) for 60 min. The effect of PYY, at 400 pmol.kg-1.h-1, on gastric acid secretion stimulated by either 2-DG or PG (1 micrograms.kg-1.h-1, i.v.) was studied after treatment with propranolol (0.5 mg/kg, i.v. bolus) or phentolamine 1 mg/kg, i.v. bolus). PYY reduced the 2-DG-stimulated secretion of gastric acid in a dose-dependent manner. PYY, given at 100 pmol.kg-1.h-1, reduced gastric acid output by 29 +/- 17%; PYY, at 200, by 41 +/- 7% (p < 0.05), and PYY, at 400, by 52 +/- 8% (p < 0.05). The inhibitory action of PYY on 2-DG-stimulated secretion of gastric acid persisted after treatment with phentolamine (69 +/- 14%; p < 0.05), but it was blocked by treatment with propranolol.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0026618207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026618207&partnerID=8YFLogxK

M3 - Article

C2 - 1364034

AN - SCOPUS:0026618207

VL - 1

SP - 40

EP - 45

JO - Neuro-Signals

JF - Neuro-Signals

SN - 1424-862X

IS - 1

ER -