Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion

F. Lluis, Guillermo Gomez, M. Fujimura, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Peptide YY (PYY) is a recently isolated gut peptide that is found primarily in the mucosal endocrine cells of the terminal ileum, colon, and rectum of several mammalian species, including humans. The purpose of this study was to characterize the effect of PYY on pancreatic exocrine secretion in six conscious dogs prepared with pancreatic and gastric fistulas. In control experiments, pancreatic exocrine secretion was stimulated by either intravenous (i.v.) administration of secretin (100 ng/kg/h), cholecystokinin-8 (50 ng/kg/h), enurotensin (5 μg/kg/h), or 2-deoxy-D-glucose (75 mg/kg); or by the intraduodenal infusion of hydrochloric acid (4 mEq/h), a mixture of amino acids (phenylalanine + tryptophan at 5 mmol/h), sodium oleate (9 mmol/h), or a liquid meal. On separate days, PYY (12.5, 25, 50, 100, 200, or 400 pmol/kg/h) was given intravenously in combination with one of the above pancreatic secretagogues. Intravenous PYY at 200 and 400 pmol/kg/h inhibited secretin-stimulated pancreatic bicarbonate output significantly (p < 0.05). Pancreatic bicarbonate and protein responses to all pancreatic secretagogues were reduced significantly (p < 0.05) by PYY at 400 pmol/kg/h. Intravenous administration of atropine (0.6 mg bolus, followed by 0.02 mg/kg/h) did not abolish the ability of PYY to inhibit secretin-stimulated pancreatic bicarbonate secretion. This study demonstrates that PYY can inhibit nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion in the dog; its mechanism of action appears to be independent of cholinergic innervation.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalPancreas
Volume2
Issue number4
StatePublished - 1987

Fingerprint

Peptide YY
Food
Secretin
Bicarbonates
Intravenous Administration
Gastric Fistula
Dogs
Pancreatic Fistula
Endocrine Cells
Hydrochloric Acid
Deoxyglucose
Phenylalanine
Atropine
Ileum
Rectum
Tryptophan
Cholinergic Agents
Meals
Colon
Amino Acids

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Lluis, F., Gomez, G., Fujimura, M., Greeley, G. H., & Thompson, J. C. (1987). Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion. Pancreas, 2(4), 454-462.

Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion. / Lluis, F.; Gomez, Guillermo; Fujimura, M.; Greeley, G. H.; Thompson, J. C.

In: Pancreas, Vol. 2, No. 4, 1987, p. 454-462.

Research output: Contribution to journalArticle

Lluis, F, Gomez, G, Fujimura, M, Greeley, GH & Thompson, JC 1987, 'Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion', Pancreas, vol. 2, no. 4, pp. 454-462.
Lluis F, Gomez G, Fujimura M, Greeley GH, Thompson JC. Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion. Pancreas. 1987;2(4):454-462.
Lluis, F. ; Gomez, Guillermo ; Fujimura, M. ; Greeley, G. H. ; Thompson, J. C. / Peptide YY inhibits nutrient-, hormonal-, and vagally-stimulated pancreatic exocrine secretion. In: Pancreas. 1987 ; Vol. 2, No. 4. pp. 454-462.
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