Peptide YY inhibits the insulinotropic action of gastric inhibitory polypeptide

Yan Shi Guo, Pomila Singh, Edwin Draviam, George H. Greeley, James C. Thompson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Peptide YY (PYY) is released from the gut after ingestion of fat or after a meal. The purpose of this investigation was to examine the effect of PYY on gastric inhibitory polypeptide (GIP)-stimulated insulin release in conscious dogs with gastric and duodenal fistulas. In control experiments, 6 dogs received GIP (400 pmol/kg, i.v., for 1 h) and glucose (0.6 g/kg, i.v., for 1 h); the integrated insulin response over a 1-h period was 142 ± 32.7 ng-60 min/ml. The plasma GIP levels achieved by this procedure were similar to those observed by intraduodenal infusion of Lipomul (2 ml/min), suggesting that the dose of GIP used was within the physiologic range. Intravenous infusion of three different doses of PYY (100, 200, or 400 pmol/kg · h) caused a significant inhibition of insulin release stimulated by GIP + glucose; the integrated insulin response was reduced to 105, 88, and 79 ng-60 min/ml, respectively. On the other hand, PYY (400 pmol/ kg · h) had no effect on insulin secretion induced by intravenous glucose (0.6 g/kg · h) alone. These results indicate that PYY specifically inhibits the insulinotropic action of GIP and that PYY may play a negative-feedback regulatory role in the enteroinsular axis.

Original languageEnglish (US)
Pages (from-to)690-694
Number of pages5
JournalGastroenterology
Volume96
Issue number3
DOIs
StatePublished - Jan 1 1989

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Gastric Inhibitory Polypeptide
Peptide YY
Insulin
Glucose
Gastric Fistula
Dogs
Corn Oil
Intravenous Infusions
Meals
Eating
Fats

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Peptide YY inhibits the insulinotropic action of gastric inhibitory polypeptide. / Guo, Yan Shi; Singh, Pomila; Draviam, Edwin; Greeley, George H.; Thompson, James C.

In: Gastroenterology, Vol. 96, No. 3, 01.01.1989, p. 690-694.

Research output: Contribution to journalArticle

Guo, Yan Shi ; Singh, Pomila ; Draviam, Edwin ; Greeley, George H. ; Thompson, James C. / Peptide YY inhibits the insulinotropic action of gastric inhibitory polypeptide. In: Gastroenterology. 1989 ; Vol. 96, No. 3. pp. 690-694.
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