Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion

Felix Lluis, Guillermo Gomez, Masaki Fujimura, George H. Greeley, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticle

13 Scopus citations


Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 μg/kg/h)-stimulated gastric acid output (P < 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 ± 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 ± 12%. The mean integrated release of secretin response to duodenal acidification (3.9 ± 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 ± 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalRegulatory Peptides
Issue number3-4
StatePublished - Aug 17 1987



  • Enterogastrone
  • Pentagastrin
  • Secretin radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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