Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion

Felix Lluis; Guillermo Gomez; Masaki Fujimura; George H. Greeley; Courtney M. Townsend; James C. Thompson

doi:10.1016/0167-0115(87)90004-8

Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion

Felix Lluis, Guillermo Gomez, Masaki Fujimura, George H. Greeley, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 μg/kg/h)-stimulated gastric acid output (P < 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 ± 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 ± 12%. The mean integrated release of secretin response to duodenal acidification (3.9 ± 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 ± 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.

Original language	English (US)
Pages (from-to)	155-163
Number of pages	9
Journal	Regulatory Peptides
Volume	18
Issue number	3-4
DOIs	https://doi.org/10.1016/0167-0115(87)90004-8
State	Published - Aug 17 1987
Externally published	Yes

Keywords

Enterogastrone
Pentagastrin
Secretin radioimmunoassay

ASJC Scopus subject areas

Physiology
Biochemistry
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(87)90004-8

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title = "Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion",

abstract = "Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 μg/kg/h)-stimulated gastric acid output (P < 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 ± 7\%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 ± 12\%. The mean integrated release of secretin response to duodenal acidification (3.9 ± 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 ± 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.",

keywords = "Enterogastrone, Pentagastrin, Secretin radioimmunoassay",

author = "Felix Lluis and Guillermo Gomez and Masaki Fujimura and Greeley, \{George H.\} and Townsend, \{Courtney M.\} and Thompson, \{James C.\}",

note = "Funding Information: The authors thank Mrs. Kelly Lee for her assistance in the preparation of the manuscript and Mrs. Freddie Hill and Mr. Robert Washington for their technical assistance. F. L. was the recipient of a Fundacion Juan March of Spain Fellowship. This study was supported by grants from the National Institute of Health (ROI DK 15241, POI DK 35608, RCDA CA 00854) and a grant from the American Cancer Society (PDT-220).",

year = "1987",

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doi = "10.1016/0167-0115(87)90004-8",

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T1 - Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion

AU - Lluis, Felix

AU - Gomez, Guillermo

AU - Fujimura, Masaki

AU - Greeley, George H.

AU - Townsend, Courtney M.

AU - Thompson, James C.

N1 - Funding Information: The authors thank Mrs. Kelly Lee for her assistance in the preparation of the manuscript and Mrs. Freddie Hill and Mr. Robert Washington for their technical assistance. F. L. was the recipient of a Fundacion Juan March of Spain Fellowship. This study was supported by grants from the National Institute of Health (ROI DK 15241, POI DK 35608, RCDA CA 00854) and a grant from the American Cancer Society (PDT-220).

PY - 1987/8/17

Y1 - 1987/8/17

N2 - Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 μg/kg/h)-stimulated gastric acid output (P < 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 ± 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 ± 12%. The mean integrated release of secretin response to duodenal acidification (3.9 ± 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 ± 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.

AB - Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 μg/kg/h)-stimulated gastric acid output (P < 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 ± 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 ± 12%. The mean integrated release of secretin response to duodenal acidification (3.9 ± 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 ± 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.

KW - Enterogastrone

KW - Pentagastrin

KW - Secretin radioimmunoassay

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ER -

Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion

Abstract

Keywords

ASJC Scopus subject areas

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