Peptides

Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons

Jeffery L. Barker, Donna L. Gruol, Li-Yen Huang, John F. MacDonald, Thomas G. Smith

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Intracellular recordings from mouse spinal neurons growing in monolayer culture were used to study the effects of opioid peptides and substance P on neuronal excitability. Three actions were observed: 1) transmitter-like actions, including a presumptive increase in Cl- conductance and a rapidly desensitizing excitation; 2) modulation of amino acid responses in the absence of, or independent of any other membrane effects; and 3) alteration in spike threshold in the absence of, or independent of any other membrane effects. All three types of effect were observed on the same cell. The same general classes of chemical excitability have been observed with a variety of non-peptide substances, indicating that the multiple effects of peptides are superficially not unique.

Original languageEnglish (US)
Pages (from-to)63-82
Number of pages20
JournalNeuropeptides
Volume1
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Neurons
Pharmacology
Membranes
Peptides
Opioid Peptides
Substance P
Transmitters
Monolayers
Modulation
Amino Acids
peptide P

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Peptides : Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons. / Barker, Jeffery L.; Gruol, Donna L.; Huang, Li-Yen; MacDonald, John F.; Smith, Thomas G.

In: Neuropeptides, Vol. 1, No. 1, 1980, p. 63-82.

Research output: Contribution to journalArticle

Barker, Jeffery L. ; Gruol, Donna L. ; Huang, Li-Yen ; MacDonald, John F. ; Smith, Thomas G. / Peptides : Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons. In: Neuropeptides. 1980 ; Vol. 1, No. 1. pp. 63-82.
@article{ee3e0302e5e64d21aeebfc02bed6fbb6,
title = "Peptides: Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons",
abstract = "Intracellular recordings from mouse spinal neurons growing in monolayer culture were used to study the effects of opioid peptides and substance P on neuronal excitability. Three actions were observed: 1) transmitter-like actions, including a presumptive increase in Cl- conductance and a rapidly desensitizing excitation; 2) modulation of amino acid responses in the absence of, or independent of any other membrane effects; and 3) alteration in spike threshold in the absence of, or independent of any other membrane effects. All three types of effect were observed on the same cell. The same general classes of chemical excitability have been observed with a variety of non-peptide substances, indicating that the multiple effects of peptides are superficially not unique.",
author = "Barker, {Jeffery L.} and Gruol, {Donna L.} and Li-Yen Huang and MacDonald, {John F.} and Smith, {Thomas G.}",
year = "1980",
doi = "10.1016/0143-4179(80)90010-4",
language = "English (US)",
volume = "1",
pages = "63--82",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - Peptides

T2 - Pharmacological evidence for three forms of chemical excitability in cultured mouse spinal neurons

AU - Barker, Jeffery L.

AU - Gruol, Donna L.

AU - Huang, Li-Yen

AU - MacDonald, John F.

AU - Smith, Thomas G.

PY - 1980

Y1 - 1980

N2 - Intracellular recordings from mouse spinal neurons growing in monolayer culture were used to study the effects of opioid peptides and substance P on neuronal excitability. Three actions were observed: 1) transmitter-like actions, including a presumptive increase in Cl- conductance and a rapidly desensitizing excitation; 2) modulation of amino acid responses in the absence of, or independent of any other membrane effects; and 3) alteration in spike threshold in the absence of, or independent of any other membrane effects. All three types of effect were observed on the same cell. The same general classes of chemical excitability have been observed with a variety of non-peptide substances, indicating that the multiple effects of peptides are superficially not unique.

AB - Intracellular recordings from mouse spinal neurons growing in monolayer culture were used to study the effects of opioid peptides and substance P on neuronal excitability. Three actions were observed: 1) transmitter-like actions, including a presumptive increase in Cl- conductance and a rapidly desensitizing excitation; 2) modulation of amino acid responses in the absence of, or independent of any other membrane effects; and 3) alteration in spike threshold in the absence of, or independent of any other membrane effects. All three types of effect were observed on the same cell. The same general classes of chemical excitability have been observed with a variety of non-peptide substances, indicating that the multiple effects of peptides are superficially not unique.

UR - http://www.scopus.com/inward/record.url?scp=0019128244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019128244&partnerID=8YFLogxK

U2 - 10.1016/0143-4179(80)90010-4

DO - 10.1016/0143-4179(80)90010-4

M3 - Article

VL - 1

SP - 63

EP - 82

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 1

ER -