Percentages of dorsal root axons immunoreactive for galanin are higher than those immunoreactive for calcitonin gene-related peptide in the rat

Caroline M. Klein, Karin N. Westlund, Richard E. Coggeshall

Research output: Contribution to journalArticle

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The present study shows that 28% of the myelinated and 27% of the unmyelinated axons in the L5 and S1 rat dorsal roots are immunolabeled for galanin. By contrast only 10% of the myelinated and 15% of the unmyelinated axons are immunolabeled for calcitonin gene-related peptide, which is the numerically predominant primary afferent peptide marker for dorsal root ganglion cells. Thus galanin, because of its presence in so many primary afferent fibers, emerges as an important primary afferent marker. In addition, since our data also show that galanin is present predominantly in unmyelinated and fine myelinated sensory axons, a hypothesis is that it is particularly concerned with the transmission of noxious information.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - Jun 11 1990



  • Calcitonin gene-related peptide
  • Dorsal root axon
  • Galanin
  • Immunocytochemistry
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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