Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors

Stephen R. Chen, Melissa M. Chen, Chibawanye Ene, Frederick F. Lang, Peter Kan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background Survival for glioblastoma remains very poor despite decades of research, with a 5-year survival of only 5%. The technological improvements that have revolutionized treatment of ischemic stroke and brain aneurysms have great potential in providing more precise and selective delivery of cancer therapeutic agents to brain tumors. Methods We describe for the first time the use of perfusion guidance to enhance the precision of endovascular super-selective intra-arterial (ESIA) infusions of mesenchymal stem cells loaded with Delta-24 (MSC-D24) in the treatment of glioblastoma (NCT 03896568). Results MRI imaging, which best defines the location of the tumor, is co-registered and fused with the patient’s position using cone beam CT, resulting in optimal vessel selection and confirmation of targeted delivery through volumetric perfusion imaging. Conclusions This technique of perfusion guided-ESIA injections (PG-ESIA) enhances our ability to perform targeted super-selective delivery of therapeutic agents for brain tumors.

Original languageEnglish (US)
JournalJournal of neurointerventional surgery
Volume14
Issue number6
DOIs
StatePublished - Jun 2022

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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