Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries

Ronald Tilton, Charles Kilo, Joseph R. Williamson

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

In order to elucidate the structure and function of pericytes, we have utilized electron microscopy and morphometric techniques to examine pericyte ultrastructure and to characterize their relationship to endothelial cells in rat hearts and rat and human skeletal muscle. Ultrastructural features of pericytes (in all three tissues) and their distribution along capillaries (84 and 95% of sectioned vessels from rat cardiac and skeletal muscle, respectively) were similar. On the other hand, pericyte secondary processes in heart and skeletal muscle differed markedly; those in skeletal muscle were larger and encircled capillaries to a greater extent than in rat hearts (20 vs 10% of vessel circumferences, respectively) and their interactions with endothelium were more intimate and complex. In both rat and human skeletal muscle, pericyte secondary processes penetrate deeply into endothelial cells and interdigitate with them extensively; likewise, endothelial evaginations protrude deeply into pericytes. These phenomena are rarely observed in rat cardiac muscle. Both myelinated and unmyelinated axons are closely associated with cardiac capillaries and pericytes, but are virtually absent from skeletal muscle microvasculatures. These differences documented in pericyte-endothelial topological relationships in heart and skeletal muscle support the concept that pericyte function may vary in different tissues.

Original languageEnglish (US)
Pages (from-to)325-335
Number of pages11
JournalMicrovascular Research
Volume18
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

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Pericytes
Muscle
Myocardium
Skeletal Muscle
Rats
Endothelial cells
Endothelial Cells
Tissue
Tissue Distribution
Microvessels
Electron microscopy
Endothelium
Axons
Electron Microscopy

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries. / Tilton, Ronald; Kilo, Charles; Williamson, Joseph R.

In: Microvascular Research, Vol. 18, No. 3, 1979, p. 325-335.

Research output: Contribution to journalArticle

Tilton, Ronald ; Kilo, Charles ; Williamson, Joseph R. / Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries. In: Microvascular Research. 1979 ; Vol. 18, No. 3. pp. 325-335.
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