Perillyl Alcohol Attenuates in vitro Angiogenesis, Modulates Angiogenic Factor Production and Inhibits Cell Proliferation and Survival in Endothelial and Tumour Cells

H. Loutrari, V. Skouridou, F. N. Kolisis, C. Roussos, Andreas Papapetropoulos

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Anti-angiogenic therapy is one of the most promising approaches to control cancer. In this work we studied the effects of perillyl alcohol (POH), a dietary monoterpene with in vivo anti-cancer activity on in vitro angiogenesis, expression of angiogenic ligands and cell proliferation/apoptosis using endothelial and tumour cells. We have shown that POH attenuates the capillary-like organization of cultured endothelial cells, decreases the expression of vascular endothelial growth factor (VEGF) by cancer cells, increases the expression of Angiopoietin 2 (Ang2) by endothelial cells and inhibits cell proliferation and survival in both cell types. We have also demonstrated that POH inhibits the phosphorylation of two key signaling molecules: Akt in endothelial cells and Erk1/2 in cancer cells.

Original languageEnglish (US)
Pages (from-to)30-32
Number of pages3
JournalReview of Clinical Pharmacology and Pharmacokinetics, International Edition
Volume18
Issue number1
StatePublished - Mar 19 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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